PAPSS2抗体;PAPSS2 Antibody—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P10200(PAPSS2 Antibody) at dilution 1/60. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using P10200(PAPSS2 Antibody) at dilution 1/60. (Original magnification: ×200)    

  
  

The PAPSS2 (3'-phosphoadenosine 5'-phosphosulfate synthase 2) antibody is a tool used to detect and study the PAPSS2 enzyme, a critical player in sulfur metabolism. PAPSS2 catalyzes the synthesis of 3'-phosphoadenosine 5'-phosphosulfate (PAPS), the universal sulfate donor for sulfation reactions. These reactions are essential for post-translational modifications of proteins, proteoglycans, and steroids, influencing extracellular matrix structure, cell signaling, and hormone regulation.

Research on PAPSS2 is closely tied to skeletal development and connective tissue disorders. Mutations in the PAPSS2 gene are linked to autosomal recessive brachyolmia and spondyloepimetaphyseal dysplasia (SEMD), characterized by short stature, skeletal deformities, and joint abnormalities. The antibody aids in studying PAPSS2 expression patterns in tissues like cartilage, liver, and growth plates, where its activity is crucial for sulfation of glycosaminoglycans (e.g., chondroitin sulfate) in proteoglycans, ensuring proper bone and cartilage formation.

In experimental models, PAPSS2 antibodies are employed in techniques like Western blotting, immunohistochemistry, and immunofluorescence to assess protein localization, expression levels, and interactions. They also help explore PAPSS2's role in metabolic syndromes, steroid hormone regulation, and cancer progression, where altered sulfation may influence tumor microenvironment and metastasis. Validating antibody specificity through knockout controls is critical due to potential cross-reactivity with related isoforms like PAPSS1.