ARIH2抗体;ARIH2 Antibody—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P02471(CCM2 Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

The ARIH2 (Ariadne Homolog 2) antibody is a research tool used to study the ARIH2 protein, a member of the E3 ubiquitin ligase family involved in the ubiquitin-proteasome system. ARIH2. also known as TRIAD1. regulates protein degradation by tagging substrates with ubiquitin, influencing cellular processes like immune response, DNA repair, and apoptosis. Structurally, it contains a RING-between-RING (RBR) domain, characteristic of RBR E3 ligases, which enables interaction with E2 ubiquitin-conjugating enzymes.

ARIH2 plays a critical role in immune regulation, particularly in modulating T-cell receptor (TCR) signaling and NF-κB pathway activity. It acts as a negative feedback regulator to prevent excessive immune activation, making it a focus in autoimmune and inflammatory disease research. Dysregulation of ARIH2 has been linked to cancers, viral infections, and autoimmune disorders, highlighting its therapeutic potential.

ARIH2 antibodies are essential for detecting and quantifying ARIH2 expression in techniques like Western blotting, immunohistochemistry, and immunofluorescence. They help elucidate ARIH2’s tissue distribution, interaction partners, and post-translational modifications. Researchers also use these antibodies to explore ARIH2’s role in disease mechanisms, such as its tumor-suppressive or oncogenic effects in different cancers. The development of specific, high-affinity ARIH2 antibodies remains vital for advancing molecular diagnostics and targeted therapies.