ZNF256抗体;ZNF256 Antibody—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using P10180(ZNF256 Antibody) at dilution 1/120. (Original magnification: ×200)    

  
  

The ZNF256 antibody is a research tool designed to detect and study the ZNF256 protein, a member of the zinc finger protein (ZFP) family. Zinc finger proteins are characterized by conserved Cys₂-His₂ (C2H2) zinc finger domains, which enable sequence-specific DNA binding and participation in transcriptional regulation. ZNF256. also known as HKR3. is a Krüppel-associated box (KRAB)-containing ZFP, suggesting roles in chromatin remodeling, gene silencing, or transcriptional repression through interactions with co-repressor complexes. Its exact biological functions remain under investigation, but it is hypothesized to regulate gene expression during development, differentiation, or cellular stress responses.

Antibodies targeting ZNF256 are typically developed in host species like rabbits or mice using immunogenic peptides or recombinant protein fragments. These antibodies are validated for applications such as Western blotting, immunohistochemistry (IHC), immunofluorescence (IF), or chromatin immunoprecipitation (ChIP) to assess protein expression, localization, and DNA-binding activity. ZNF256 has been studied in contexts like cancer, where dysregulation of zinc finger proteins may contribute to tumorigenesis or metastasis, though specific mechanisms involving ZNF256 are not fully elucidated. Researchers utilize ZNF256 antibodies to explore its tissue-specific expression patterns, interaction partners, and potential roles in disease pathways, aiding in the broader understanding of transcriptional regulation networks.