RRP8抗体;RRP8 Antibody—艾普蒂 新品

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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Human cerebella tissue, K562 cell lysates, Primary antibody: P10170(RRP8 Antibody) at dilution 1/1000, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 30 seconds    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P10170(RRP8 Antibody) at dilution 1/80. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human breast cancer tissue using P10170(RRP8 Antibody) at dilution 1/80. (Original magnification: ×200)    

  
  

The RRP8 antibody is a crucial tool for studying the RRP8 protein, a conserved eukaryotic nucleolar protein implicated in ribosome biogenesis and epigenetic regulation. RRP8 (Ribonuclease P/MRP Subunit RRP8), also known as C9orf85 or NET15. is a core component of the RNase P and RNase MRP complexes, which are involved in processing ribosomal RNA (rRNA) precursors and maintaining ribosomal function. Beyond its role in ribosome synthesis, RRP8 interacts with chromatin-modifying enzymes, such as histone deacetylases (HDACs) and DNA methyltransferases, suggesting a dual role in RNA metabolism and epigenetic silencing. Studies highlight its involvement in cell cycle regulation, DNA damage response, and nucleolar stress pathways.

Antibodies targeting RRP8 enable researchers to investigate its expression, localization, and interactions via techniques like Western blotting, immunofluorescence, and immunoprecipitation. These antibodies are particularly valuable in cancer research, as RRP8 dysregulation has been linked to tumorigenesis, including colorectal and breast cancers. Additionally, RRP8’s association with neurological disorders, such as spinocerebellar ataxia, underscores its broader biomedical relevance. Commercially available RRP8 antibodies are typically raised against specific epitopes, with validation across species (human, mouse, rat) and applications. Proper validation (e.g., knockout controls) is critical due to potential cross-reactivity with unrelated proteins. Overall, RRP8 antibodies facilitate mechanistic insights into nucleolar functions, epigenetic control, and disease pathways.