ASTN2抗体;ASTN2 Antibody—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P10162(ASTN2 Antibody) at dilution 1/80. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P10162(ASTN2 Antibody) at dilution 1/80. (Original magnification: ×200)    

  
  

The ASTN2 antibody is a research tool designed to detect and study astrotactin-2 (ASTN2), a protein encoded by the ASTN2 gene. ASTN2 is a transmembrane glycoprotein predominantly expressed in the central nervous system, where it plays a role in neuronal migration, synaptic adhesion, and neurodevelopment. It interacts with extracellular matrix components and cell-surface receptors to guide neuronal positioning during brain development. Dysregulation of ASTN2 has been implicated in neurodevelopmental and neuropsychiatric disorders, including autism spectrum disorder (ASD), schizophrenia, and intellectual disability, with genetic studies linking ASTN2 mutations or copy-number variations to these conditions.

ASTN2 antibodies are widely used in neuroscience research to investigate protein expression, localization, and function in cellular and animal models. They enable techniques like Western blotting, immunohistochemistry, and immunofluorescence to visualize ASTN2 distribution in brain tissues or cultured neurons. Additionally, these antibodies aid in exploring molecular mechanisms underlying ASTN2-associated pathologies, such as disrupted synaptic plasticity or aberrant neural circuitry. Commercial ASTN2 antibodies are typically raised in hosts like rabbits or mice, targeting specific epitopes within the protein's extracellular or intracellular domains. Validation steps, including knockout controls and peptide blocking, are essential to ensure specificity, given potential homology with related proteins like ASTN1. Research using ASTN2 antibodies continues to clarify its role in brain development and disease pathways.