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  • SCCPDH抗体;SCCPDH Antibody—艾普蒂
  • SCCPDH抗体;SCCPDH Antibody—艾普蒂
  • SCCPDH抗体;SCCPDH Antibody—艾普蒂

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SCCPDH抗体;SCCPDH Antibody—艾普蒂

Rabbit Polyclonal SCCPDH Antibody
询价 20μl 起订
50μl 起订
100μl 起订
上海 更新日期：2025-05-25

上海切尔齐生物科技有限公司

VIP1年
联系人：周经理
电话：027-19371278702拨打
手机：18008634902 拨打
邮箱：nuodina88@163.com

产品详情:

中文名称：
SCCPDH抗体
英文名称：
Rabbit Polyclonal SCCPDH Antibody
品牌：
艾普蒂
产地：
武汉
保存条件：
Stored at -20°C for 5323 year. Avoid repeated freeze / thaw cycles.
产品类别：
抗体
重组：
否
应用：
WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性：
Human,Mouse,Rat
宿主：
Rabbit
偶联物：
无
靶点：
SCCPDH

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/50-1/300 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

产品详情

AliasesNET11; CGI-49
WB Predicted band size47 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenFusion protein of human SCCPDH
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-3: Human fetal liver tissue, PC-3 and A172 cell lysates, Primary antibody: P10156(SCCPDH Antibody) at dilution 1/1000, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 1 minute    


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       The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using P10156(SCCPDH Antibody) at dilution 1/85. (Original magnification: ×200)    


  •  

     

       The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P10156(SCCPDH Antibody) at dilution 1/85. (Original magnification: ×200)    


           

参考文献

以下是关于SCCPDH抗体的模拟参考文献示例(注：文献信息为假设，供参考，建议通过PubMed或Google Scholar查询真实文献)：

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1. **文献名称**: *SCCPDH overexpression correlates with poor prognosis in gastric cancer and promotes tumor progression*

**作者**: Wang, X. et al.

**摘要**: 本研究通过免疫组化(使用抗SCCPDH多克隆抗体)发现，SCCPDH在胃癌组织中高表达，且与患者生存率降低相关。实验表明SCCPDH通过调控鞘脂代谢促进肿瘤侵袭。

2. **文献名称**: *Development and validation of a monoclonal antibody targeting SCCPDH for lipid metabolism studies*

**作者**: Smith, J. et al.

**摘要**: 文章报道了一种新型抗SCCPDH单克隆抗体的开发，验证了其在Western blot和免疫荧光中的特异性，并应用于肝癌细胞模型，揭示SCCPDH在脂质代谢重编程中的作用。

3. **文献名称**: *SCCPDH knockdown inhibits cell proliferation via ceramide pathway in colorectal cancer*

**作者**: Zhang, L. et al.

**摘要**: 通过RNA干扰和抗SCCPDH抗体检测，研究发现抑制SCCPDH可减少结直肠癌细胞增殖，机制涉及鞘脂代谢失衡诱导的凋亡，提示其作为潜在治疗靶点。

4. **文献名称**: *SCCPDH antibody-based biosensor for early diagnosis of liver fibrosis*

**作者**: Chen, Y. et al.

**摘要**: 研究团队利用高亲和力抗SCCPDH抗体开发了一种生物传感器，用于检测血清中SCCPDH水平，成功在小鼠模型中实现肝纤维化的早期诊断。

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建议通过学术数据库检索**SCCPDH(可能为“Saccharomyces cerevisiae Ceramide-Phosphate Dehydrogenase”或相关基因)**的正式研究，关键词可结合“SCCPDH antibody”、“cancer”、“lipid metabolism”等。

       

背景信息

SCCPDH (Saccharopine dehydrogenase) antibodies target an enzyme involved in the lysine degradation pathway, specifically catalyzing the conversion of saccharopine to α-ketoglutarate and L-glutamate. This mitochondrial enzyme, encoded by the *SCCPDH* gene (located on human chromosome 15q25.3), plays a role in cellular metabolism and energy homeostasis. Structurally, SCCPDH contains conserved NAD-binding and catalytic domains, critical for its enzymatic activity.

Interest in SCCPDH antibodies stems from its potential implications in disease. Elevated SCCPDH expression has been observed in certain cancers, including hepatocellular carcinoma, colorectal cancer, and prostate cancer, where it may promote cell proliferation or inhibit apoptosis. Antibodies against SCCPDH are thus valuable tools for studying its expression patterns, subcellular localization, and mechanistic roles in tumorigenesis via techniques like Western blotting, immunohistochemistry, or immunofluorescence.

Additionally, SCCPDH has been linked to metabolic disorders and neurodegenerative conditions, though its precise role remains under investigation. Research using SCCPDH antibodies could clarify its involvement in lysine metabolism dysregulation and its crosstalk with signaling pathways like mTOR or AMPK. Such studies may inform therapeutic strategies targeting SCCPDH in precision medicine or biomarker development.

       
SCCPDH抗体;SCCPDH;SCCPDH Antibody;

公司简介

生物技术有限公司

成立日期 (2年)
注册资本 20万人民币
员工人数 1-10人
年营业额 ￥ 100万以内
经营模式 贸易,工厂,试剂,定制,服务
主营行业 抗体,植物生物技术,细胞培养,蛋白组学

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