COPS3抗体;COPS3 Antibody—艾普蒂

+ +

•  

   

     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: 293T cell lysate, Primary antibody: P10153(COPS3 Antibody) at dilution 1/450, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 20 seconds    

  
  

•  

   

     The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P10153(COPS3 Antibody) at dilution 1/60. (Original magnification: ×200)    

  
  

**Background of COPS3 Antibody**

The COP9 signalosome complex subunit 3 (COPS3), also known as CSN3. is a key component of the COP9 signalosome (CSN), a highly conserved multifunctional protein complex involved in regulating ubiquitin-proteasome-mediated protein degradation. The CSN complex, composed of eight subunits (CSN1–CSN8), plays a critical role in modulating cullin-RING ubiquitin ligases (CRLs), which are essential for substrate recognition in ubiquitination. COPS3. encoded by the *COPS3* gene, contributes to the structural stability and enzymatic activity of the CSN complex, particularly in regulating deneddylation (removal of NEDD8 from cullins) and maintaining CRL activity.

COPS3 antibodies are immunological tools designed to detect and quantify COPS3 protein expression in various experimental settings, such as Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). These antibodies are crucial for studying COPS3's biological functions, including its role in cell cycle regulation, DNA damage response, and apoptosis. Dysregulation of COPS3 has been implicated in cancer progression, neurodegenerative disorders, and immune diseases, making it a potential therapeutic target.

Validated COPS3 antibodies exhibit specificity for human, mouse, or rat COPS3. depending on their design, and are widely used in both basic research and clinical studies to explore COPS3-associated pathways and their impact on disease mechanisms.