TSC22D3抗体;TSC22D3 Antibody—艾普蒂

+ +

•  

   

     The image is immunohistochemistry of paraffin-embedded Human colon cancer tissue using P08369(TSC22D3 Antibody) at dilution 1/40. (Original magnification: ×200)    

  
  

•  

   

     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P08369(TSC22D3 Antibody) at dilution 1/40. (Original magnification: ×200)    

  
  

The TSC22D3 (TSC22 domain family member 3) antibody is a research tool targeting the protein encoded by the TSC22D3 gene, also known as glucocorticoid-induced leucine zipper (GILZ). This gene is a key mediator of glucocorticoid signaling, playing a critical role in immune regulation, inflammation, and stress responses. GILZ is induced by glucocorticoids and regulates cellular processes by interacting with transcription factors like AP-1 and NF-κB, thereby suppressing pro-inflammatory pathways. It influences immune cell differentiation, apoptosis, and metabolic homeostasis.

TSC22D3 antibodies are widely used in biomedical research to detect and quantify GILZ expression in tissues or cells via techniques like Western blotting, immunohistochemistry, and flow cytometry. Studies focus on its role in autoimmune diseases (e.g., rheumatoid arthritis, lupus), cancer (modulating tumor growth and drug resistance), and metabolic disorders. Researchers also explore its potential as a therapeutic target or biomarker due to its anti-inflammatory and immunosuppressive properties. Variations in GILZ expression have been linked to glucocorticoid resistance, making this antibody valuable in understanding treatment mechanisms and disease progression. Its applications extend to models of inflammation, stress adaptation, and immune tolerance.