EIF3H抗体;EIF3H Antibody—艾普蒂

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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Human adrenal pheochromocytoma and fetal brain tissue, Primary antibody: P08270(EIF3H Antibody) at dilution 1/1150, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 40 seconds    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P08270(EIF3H Antibody) at dilution 1/50. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P08270(EIF3H Antibody) at dilution 1/50. (Original magnification: ×200)    

  
  

The eukaryotic translation initiation factor 3 subunit H (EIF3H) is a critical component of the eukaryotic initiation factor 3 (eIF3) complex, which plays a central role in initiating protein synthesis by facilitating ribosome recruitment to mRNA. EIF3H, encoded by the *EIF3H* gene, is one of 13 subunits of the eIF3 complex and is essential for stabilizing the complex and regulating its activity. Studies highlight its involvement in selective translation of specific mRNAs, particularly those with complex 5' untranslated regions, influencing cellular processes such as proliferation, apoptosis, and stress responses.

EIF3H antibodies are widely used as research tools to investigate EIF3H expression, localization, and interactions in various biological contexts. Dysregulation of EIF3H has been implicated in oncogenesis, with overexpression observed in cancers like prostate, liver, and colorectal carcinomas, where it correlates with poor prognosis and enhanced tumor progression. These antibodies enable detection via techniques such as Western blotting, immunohistochemistry, and immunofluorescence, aiding in mechanistic studies of EIF3H's role in cancer and other diseases.

Research also explores EIF3H's potential as a therapeutic target, with antibodies serving as foundational tools for validating its biological and clinical relevance. Additionally, genetic variations in *EIF3H* have been linked to developmental disorders, emphasizing its broader physiological significance. Overall, EIF3H antibodies are vital for advancing understanding of translation regulation and its implications in health and disease.