TLE5抗体;TLE5 Antibody—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P07839(TLE5 Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using P07839(TLE5 Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

The TLE5 antibody is designed to detect Transducin-like enhancer of split 5 (TLE5), a member of the TLE family of transcriptional corepressors. TLE proteins, including TLE1-5 and AES/Groucho, are evolutionarily conserved and play critical roles in regulating gene expression by interacting with transcription factors, such as those in the Wnt and Notch signaling pathways. TLE5. specifically, shares a conserved structure with other TLE family members, including WD40 repeats for protein-protein interactions and a SP domain for transcriptional repression. It functions as a corepressor by recruiting histone deacetylases (HDACs) to chromatin, thereby modulating chromatin structure and suppressing target gene expression.

TLE5 is implicated in diverse biological processes, including embryonic development, cell differentiation, and tumorigenesis. Studies suggest its involvement in neural development, where it may regulate progenitor cell proliferation and differentiation. In cancer research, altered TLE5 expression has been observed in certain malignancies, linking it to tumor suppression or progression depending on context. The TLE5 antibody is widely used in research applications such as Western blotting, immunohistochemistry, and immunofluorescence to investigate protein expression patterns, subcellular localization, and interactions in both normal and diseased tissues. Commercial availability from multiple suppliers ensures its accessibility for studying TLE5's role in cellular signaling and disease mechanisms.