ACOX3抗体;ACOX3 Antibody—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using P07752(ACOX3 Antibody) at dilution 1/35. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human colon cancer tissue using P07752(ACOX3 Antibody) at dilution 1/35. (Original magnification: ×200)    

  
  

The ACOX3 antibody targets acyl-CoA oxidase 3 (ACOX3), a peroxisomal enzyme involved in the β-oxidation of branched-chain fatty acids and bile acid intermediates. ACOX3. encoded by the *ACOX3* gene, plays a specialized role in metabolizing methyl-branched fatty acyl-CoAs, distinguishing it from other acyl-CoA oxidases like ACOX1 and ACOX2. This enzyme is critical in lipid homeostasis, particularly in tissues such as the liver, testis, and brain. Research on ACOX3 has gained interest due to its potential links to metabolic disorders, neurodegenerative diseases, and cancer, though its precise physiological and pathological roles remain under investigation.

ACOX3 antibodies are typically developed using recombinant protein fragments or synthetic peptides corresponding to unique regions of the human ACOX3 protein. These antibodies are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to detect ACOX3 expression levels, tissue distribution, and subcellular localization. Commercial ACOX3 antibodies are often validated for specificity through knockout controls or siRNA silencing. Studies utilizing these antibodies have explored ACOX3's involvement in lipid metabolism dysregulation, its expression patterns in tumors, and its interaction with peroxisomal pathways. However, challenges persist in standardizing antibody performance across studies, emphasizing the need for rigorous validation in experimental models.