SPATA7抗体;SPATA7 Antibody—艾普蒂

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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: 231 cell, Primary antibody: P07633(SPATA7 Antibody) at dilution 1/250, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human colon cancer tissue using P07633(SPATA7 Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using P07633(SPATA7 Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

**Background of SPATA7 Antibody**

SPATA7 (spermatogenesis-associated protein 7), also known as C1orf64 or NYD-SP7. is a protein implicated in spermatogenesis and ciliary function. It is encoded by the *SPATA7* gene, located on human chromosome 1p36.13. SPATA7 is highly expressed in testes and retinal cells, where it plays roles in intracellular vesicle transport, photoreceptor maintenance, and cilia assembly. Structurally, it contains coiled-coil domains, suggesting involvement in protein-protein interactions.

SPATA7 antibodies are immunological tools designed to detect and study the expression, localization, and function of the SPATA7 protein. These antibodies are typically generated using recombinant SPATA7 protein fragments or synthetic peptides as immunogens. They are validated for applications such as Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF).

Research has linked *SPATA7* mutations to human diseases, including Leber congenital amaurosis (LCA) and retinitis pigmentosa (RP), highlighting its critical role in retinal integrity. In spermatogenesis, SPATA7 interacts with components of the intraflagellar transport (IFT) system, essential for sperm flagella formation. Antibodies against SPATA7 thus serve as vital reagents for investigating infertility mechanisms, ciliopathies, and retinal degeneration pathways. Their specificity and sensitivity are rigorously tested to ensure reliability in both experimental and diagnostic contexts.