MUTYH抗体;MUTYH Antibody—艾普蒂

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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Hela cells, Primary antibody: P07469(MUTYH Antibody) at dilution 1/500, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human lung cancer tissue using P07469(MUTYH Antibody) at dilution 1/25. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using P07469(MUTYH Antibody) at dilution 1/25. (Original magnification: ×200)    

  
  

The MUTYH antibody is a crucial tool in studying the MUTYH gene and its associated protein, which plays a vital role in DNA repair. MUTYH (MutY Homolog) encodes a glycosylase involved in base excision repair (BER), specifically targeting mismatched adenine residues paired with 8-oxoguanine (8-oxoG), a common oxidative DNA lesion. By excising these mismatched bases, MUTYH prevents G:C→T:A transversion mutations, maintaining genomic stability.

Biallelic mutations in MUTYH are linked to MUTYH-associated polyposis (MAP), an autosomal recessive condition characterized by colorectal polyposis and increased cancer risk. MUTYH antibodies are widely used in research to detect protein expression levels, assess cellular localization, and investigate functional deficiencies in BER pathways. They are essential for immunohistochemistry, Western blotting, and immunofluorescence studies in cancer biology and genetic disorder research.

Clinically, these antibodies aid in diagnosing MAP by identifying loss of MUTYH protein in tissue samples, complementing genetic testing. Research also explores their role in understanding tumorigenesis mechanisms, therapeutic resistance related to DNA repair defects, and potential biomarkers for cancer prognosis. The development of high-specificity MUTYH antibodies continues to advance both molecular diagnostics and targeted therapies for DNA repair-deficient cancers.