CUL5抗体;CUL5 Antibody—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using P07227(CUL5 Antibody) at dilution 1/10. (Original magnification: ×200)    

  
  

The CUL5 antibody is a research tool designed to detect and study the Cullin 5 (CUL5) protein, a core component of the Cullin-RING E3 ubiquitin ligase (CRL) complexes. CUL5 belongs to the Cullin family of scaffold proteins that play critical roles in the ubiquitin-proteasome system, mediating the targeted degradation of specific substrates through polyubiquitination. CUL5 forms part of the CRL5 complex by interacting with adaptor proteins (e.g., SOCS-box or Elongin BC) and substrate receptors, enabling substrate recognition and recruitment. This complex regulates diverse cellular processes, including cell cycle progression, DNA damage response, and viral defense mechanisms.

CUL5 antibodies are widely used in biomedical research to investigate protein expression, localization, and interactions via techniques like Western blotting, immunoprecipitation, and immunofluorescence. Dysregulation of CUL5 has been implicated in diseases such as cancer, where it may act as a tumor suppressor or promoter depending on context, and in viral infections (e.g., HIV), where viruses exploit CRL5-mediated ubiquitination to evade host immune responses. Researchers also utilize CUL5 antibodies to explore its role in developmental disorders and neurodegenerative conditions linked to ubiquitin system dysfunction. The specificity and sensitivity of these antibodies are critical for elucidating CUL5's molecular mechanisms and therapeutic potential.