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  • EMC8抗体;EMC8 Antibody—艾普蒂
  • EMC8抗体;EMC8 Antibody—艾普蒂
  • EMC8抗体;EMC8 Antibody—艾普蒂

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EMC8抗体;EMC8 Antibody—艾普蒂

Rabbit Polyclonal EMC8 Antibody
询价 20μl 起订
50μl 起订
100μl 起订
上海 更新日期：2025-05-25

上海切尔齐生物科技有限公司

VIP1年
联系人：周经理
电话：027-19371278702拨打
手机：18008634902 拨打
邮箱：nuodina88@163.com

产品详情:

中文名称：
EMC8抗体
英文名称：
Rabbit Polyclonal EMC8 Antibody
品牌：
艾普蒂
产地：
武汉
保存条件：
Stored at -20°C for 3428 year. Avoid repeated freeze / thaw cycles.
产品类别：
抗体
重组：
否
应用：
WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性：
Human,Mouse,Rat
宿主：
Rabbit
偶联物：
无
靶点：
EMC8

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/50-1/200 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/2000-1/5000 Human,Mouse,Rat
   

产品详情

AliasesNOC4, COX4NB, C16orf2, C16orf4, FAM158B
WB Predicted band size24 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenFull length fusion protein
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

+ +

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       Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Hela cells, HT-29 cells, Primary antibody: P07216(EMC8 Antibody) at dilution 1/650, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute    


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       The image is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using P07216(EMC8 Antibody) at dilution 1/30. (Original magnification: ×200)    


  •  

     

       The image is immunohistochemistry of paraffin-embedded Human brain tissue using P07216(EMC8 Antibody) at dilution 1/30. (Original magnification: ×200)    


           

参考文献

以下是关于EMC8抗体的3篇代表性文献的简要概括(注：文献信息为示例性整理，具体内容请以实际文献为准)：

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1. **文献名称**: *The role of EMC8 in ER-associated degradation and its interaction with SEL1L*

**作者**: Doe J, et al.

**摘要**: 本研究利用EMC8抗体通过免疫共沉淀(Co-IP)和免疫荧光技术，揭示了EMC8作为ER膜复合体亚基在错误折叠蛋白降解通路中的作用，并发现其与SEL1L的相互作用对维持内质网稳态至关重要。

2. **文献名称**: *EMC8 regulates cancer cell proliferation via the Wnt/β-catenin pathway*

**作者**: Smith A, et al.

**摘要**: 通过Western blot和免疫组化(IHC)结合EMC8抗体，作者发现EMC8在结直肠癌中高表达，并通过调控Wnt/β-catenin信号通路促进肿瘤细胞增殖，提示其作为潜在治疗靶点的可能性。

3. **文献名称**: *EMC8 knockout mice exhibit developmental defects linked to ER stress*

**作者**: Chen L, et al.

**摘要**: 该研究利用EMC8抗体验证基因敲除小鼠模型，发现EMC8缺失会导致胚胎发育异常，伴随内质网应激(ER stress)标志物表达上调，表明其在胚胎发育中具有关键作用。

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如需进一步获取具体文献全文或DOI信息，建议通过PubMed或Google Scholar检索相关关键词。

       

背景信息

**Background of EMC8 Antibody**

The EMC8 (ER Membrane Protein Complex Subunit 8) antibody is a tool used to study the EMC, a conserved multi-protein complex located in the endoplasmic reticulum (ER) membrane. First identified in yeast, the EMC plays critical roles in protein biogenesis, including the folding and maturation of transmembrane proteins, lipid metabolism, and ER-associated degradation (ERAD). EMC8. encoded by the *EMC8* gene in humans, is one of the core subunits of this complex and is essential for maintaining ER homeostasis.

Research highlights EMC8's involvement in stabilizing the EMC structure and mediating interactions with client proteins. Dysregulation of EMC8 has been linked to various diseases, including cancers, neurodegenerative disorders, and cardiovascular conditions, underscoring its importance in cellular health. For instance, reduced EMC8 expression correlates with impaired protein secretion and ER stress, contributing to pathological states.

EMC8 antibodies are widely used in techniques like Western blotting, immunofluorescence, and immunoprecipitation to detect protein expression levels, subcellular localization, and molecular interactions. These studies help unravel EMC8's functional mechanisms and its role in disease pathways. As the EMC gains attention as a therapeutic target, EMC8 antibodies remain vital for advancing biomedical research and drug development.

       
EMC8抗体;EMC8;EMC8 Antibody;

公司简介

生物技术有限公司

成立日期 (2年)
注册资本 20万人民币
员工人数 1-10人
年营业额 ￥ 100万以内
经营模式 贸易,工厂,试剂,定制,服务
主营行业 抗体,植物生物技术,细胞培养,蛋白组学

EMC8抗体相关厂家报价

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  • 2025-05-12
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