MRGPRX2抗体;MRGPRX2 Antibody—艾普蒂

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     Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)    

  
  

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     Flow cytometric analysis of MCF-7 cells using MRGPRX2 mouse mAb (green) and negative control (red).    

  
  

MRGPRX2 (Mas-related G protein-coupled receptor X2) is a class A GPCR primarily expressed in mast cells, with roles in immune responses, inflammation, and pain modulation. Unlike traditional IgE-mediated pathways, MRGPRX2 activation triggers mast cell degranulation via neuropeptides (e.g., substance P), antimicrobial peptides, and certain drugs, contributing to pseudoallergic reactions and chronic inflammatory conditions. Its unique ligand-binding profile and signaling mechanisms have made it a therapeutic target for mast cell-related disorders, such as chronic urticaria, atopic dermatitis, and drug hypersensitivity.

Antibodies targeting MRGPRX2 are emerging as tools to study receptor function and potential therapeutics. They aim to block pathogenic mast cell activation while preserving IgE-mediated protective immunity. Recent studies highlight their ability to inhibit neuropeptide-induced inflammation and reduce symptoms in preclinical models. Challenges include ensuring specificity (to avoid cross-reactivity with homologous receptors like MRGPRX1) and optimizing pharmacokinetics for clinical use. Research also explores MRGPRX2's role in non-allergic diseases, including fibrosis and pain, expanding potential antibody applications. However, the receptor's complex ligand interactions and tissue-specific signaling require further characterization to advance antibody-based therapies.