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网站主页 AHNAK antibody AHNAK抗体
  • AHNAK抗体;AHNAK Antibody—艾普蒂
  • AHNAK抗体;AHNAK Antibody—艾普蒂
  • AHNAK抗体;AHNAK Antibody—艾普蒂

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AHNAK抗体;AHNAK Antibody—艾普蒂

Mouse Monoclonal AHNAK Antibody
询价 20μl 起订
50μl 起订
100μl 起订
上海 更新日期：2025-05-25

上海切尔齐生物科技有限公司

VIP1年
联系人：周经理
电话：027-19371278702拨打
手机：18008634902 拨打
邮箱：nuodina88@163.com

产品详情:

中文名称：
AHNAK抗体
英文名称：
Mouse Monoclonal AHNAK Antibody
品牌：
艾普蒂
产地：
武汉
保存条件：
Stored at -20°C for 1463 year. Avoid repeated freeze / thaw cycles.
产品类别：
抗体
重组：
否
应用：
WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性：
Human,Mouse,Rat
宿主：
Mouse
偶联物：
无
靶点：
AHNAK

验证与应用

应用及物种
WB1/500-1/1000 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/200 - 1/1000 Human,Mouse,Rat
ICC1/200 - 1/1000 Human,Mouse,Rat
FCM1/200 - 1/400 Human,Mouse,Rat
Elisa1/10000 Human,Mouse,Rat
   

产品详情

AliasesPM227; AHNAKRS
Entrez GeneID79026
clone8B3A4
WB Predicted band size63KDa
Host/IsotypeMouse IgG1
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenPurified recombinant fragment of human AHNAK (AA: 1-200) expressed in E. Coli.
FormulationPurified antibody in PBS with 0.05% sodium azide

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       Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)    


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       Immunofluorescence analysis of Hela cells using AHNAK mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin. Secondary antibody from Fisher (Cat#: 35503)    


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       Flow cytometric analysis of Hela cells using AHNAK mouse mAb (green) and negative control (red).    


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       Flow cytometric analysis of HepG2 cells using AHNAK mouse mAb (green) and negative control (red).    


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       Immunohistochemical analysis of paraffin-embedded human Cervical cancer tissues using AHNAK mouse mAb with DAB staining.    


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       Immunohistochemical analysis of paraffin-embedded human bladder cancer tissues using AHNAK mouse mAb with DAB staining.    


           

参考文献

以下是关于AHNAK抗体的3篇参考文献及其摘要概括：

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1. **"AHNAK interaction with the annexin 2/S100A10 complex regulates cell membrane cytoarchitecture"**

*Authors: Benaud C. et al.*

摘要：研究揭示了AHNAK通过与膜修复相关蛋白复合物(annexin 2/S100A10)的相互作用调控细胞膜结构，并开发了特异性抗体用于验证AHNAK在细胞损伤修复中的定位和功能。

2. **"AHNAK as a biomarker in breast cancer: Correlation with tumor progression"**

*Authors: Lee I.H. et al.*

摘要：利用AHNAK抗体检测乳腺癌组织中AHNAK的表达水平，发现其高表达与肿瘤侵袭性和不良预后相关，提示其作为潜在诊断标志物的价值。

3. **"AHNAK shields broken nuclear envelope in cancer cells"**

*Authors: Jaiswal J.K. et al.*

摘要：通过免疫荧光(使用AHNAK抗体)发现，AHNAK在癌细胞核膜损伤时募集至破损处，协助维持核膜完整性，为靶向癌症治疗提供新思路。

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以上文献聚焦于AHNAK抗体在机制研究(膜修复、核膜保护)及临床诊断中的应用，涵盖基础与转化医学领域。如需具体期刊信息或年份，可进一步补充检索关键词(如“AHNAK antibody cancer”或“AHNAK knockout model”)。

       

背景信息

AHNAK antibodies target the AHNAK nucleoprotein, a large (~700 kDa) scaffolding protein involved in cell membrane repair, cytoskeletal organization, and calcium signaling. Initially identified as a gene dysregulated in neuroblastoma, AHNAK is expressed in various tissues, including cardiac and skeletal muscle, epithelial cells, and neurons. Its structure features multiple repeating domains, enabling interactions with proteins like dysferlin, S100 calcium-binding proteins, and protein kinase C isoforms, which underpin its role in cell adhesion, motility, and signal transduction.

AHNAK's dual localization (nucleus/cytoplasm) and involvement in cancer progression (e.g., metastasis, epithelial-mesenchymal transition) have driven interest in developing antibodies for research and diagnostics. Commercially available AHNAK antibodies (polyclonal/monoclonal) are primarily used in Western blotting, immunofluorescence, and immunohistochemistry to study its expression patterns in diseases like cardiomyopathy, muscular dystrophy, and cancers (breast, lung, melanoma). However, antibody specificity remains a challenge due to AHNAK's size and repetitive domains, requiring careful validation via knockout controls.

Recent studies highlight AHNAK's potential as a cancer biomarker or therapeutic target, though conflicting data on its pro- or anti-tumor roles necessitate further investigation. Research-grade antibodies thus play a critical role in elucidating AHNAK's context-dependent functions in cellular homeostasis and pathology.

       
AHNAK抗体;AHNAK;AHNAK Antibody;

公司简介

生物技术有限公司

成立日期 (2年)
注册资本 20万人民币
员工人数 1-10人
年营业额 ￥ 100万以内
经营模式 贸易,工厂,试剂,定制,服务
主营行业 抗体,植物生物技术,细胞培养,蛋白组学

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