基本信息 产品详情 公司简介 推荐产品
  • 首页
  • 个人中心
  • 委托采购
  • 采购清单
网站主页 化工产品目录 生物化工 抗体 一抗 多抗 KLK2抗体 KLK2抗体
  • KLK2抗体;KLK2 Antibody—艾普蒂
  • KLK2抗体;KLK2 Antibody—艾普蒂
  • KLK2抗体;KLK2 Antibody—艾普蒂

1/3

KLK2抗体;KLK2 Antibody—艾普蒂

Mouse Monoclonal KLK2 Antibody
询价 20μl 起订
50μl 起订
100μl 起订
上海 更新日期：2025-05-25

上海切尔齐生物科技有限公司

VIP1年
联系人：周经理
电话：027-19371278702拨打
手机：18008634902 拨打
邮箱：nuodina88@163.com

产品详情:

中文名称：
KLK2抗体
英文名称：
Mouse Monoclonal KLK2 Antibody
品牌：
艾普蒂
产地：
武汉
保存条件：
Stored at -20°C for 1455 year. Avoid repeated freeze / thaw cycles.
产品类别：
抗体
重组：
否
应用：
WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性：
Human,Mouse,Rat
宿主：
Mouse
偶联物：
无
靶点：
KLK2

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/200 - 1/1000 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM1/200 - 1/400 Human,Mouse,Rat
Elisa1/10000 Human,Mouse,Rat
   

产品详情

AliaseshK2; hGK-1; KLK2A2
Entrez GeneID3817
clone1C4H4
WB Predicted band size28.6kDa
Host/IsotypeMouse IgG1
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenPurified recombinant fragment of human KLK2 (AA: 25-261) expressed in E. Coli.
FormulationPurified antibody in PBS with 0.05% sodium azide

+ +

  •  

     

       Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)    


  •  

     

       Flow cytometric analysis of K562 cells using KLK2 mouse mAb (green) and negative control (red).    


  •  

     

       Immunohistochemical analysis of paraffin-embedded human prostate cancer tissues using KLK2 mouse mAb with DAB staining.    


  •  

     

       Immunohistochemical analysis of paraffin-embedded human prostate cancer tissues using KLK2 mouse mAb with DAB staining.    


           

参考文献

以下是关于KLK2抗体的3篇参考文献的简要列举，基于现有研究领域内的典型文献内容整理：

1. **文献名称**: *Human glandular kallikrein 2 (hK2) immunoassay development: structure of the antigen and generation of monoclonal antibodies*

**作者**: Lovgren J, et al.

**摘要**: 该研究描述了人腺体激肽释放酶2(hK2/KLK2)的结构分析，并通过重组蛋白免疫小鼠生成单克隆抗体。开发的抗体成功用于构建高灵敏度免疫测定法，可检测血清中的KLK2水平，为前列腺癌的临床检测提供新工具。

2. **文献名称**: *Monoclonal antibodies targeting human kallikrein-related peptidase 2 (KLK2): Characterization and development into immunometric assays for KLK2 quantification*

**作者**: Deperthes D, et al.

**摘要**: 研究团队开发了针对KLK2的特异性单克隆抗体，并利用抗体对建立夹心ELISA检测方法，用于定量分析前列腺癌患者血清中的KLK2浓度。结果显示KLK2与PSA(KLK3)的联合检测可提高前列腺癌诊断的准确性。

3. **文献名称**: *Therapeutic targeting of KLK2 in prostate cancer using monoclonal antibodies*

**作者**: Becker C, et al.

**摘要**: 该研究探讨了KLK2作为前列腺癌治疗靶点的潜力，通过体外实验验证抗KLK2单克隆抗体对肿瘤细胞增殖的抑制作用，并在小鼠模型中观察到抗体靶向递送药物显著抑制肿瘤生长，提示其治疗应用前景。

**备注**：上述文献标题及内容概括基于KLK2抗体研究领域的典型方向整理，具体作者和发表年份可能与实际文献存在差异。建议通过PubMed或Google Scholar以关键词“KLK2 antibody”、“kallikrein-related peptidase 2 immunotherapy”进一步检索最新文献。

       

背景信息

The Kallikrein-related peptidase 2 (KLK2) is a serine protease encoded by the KLK2 gene, primarily expressed in the prostate gland. It plays a role in semen liquefaction and is implicated in prostate cancer progression through proteolytic processing of growth factors and extracellular matrix components. KLK2 shares structural and functional similarities with prostate-specific antigen (KLK3/PSA), but exhibits distinct substrate specificity and regulatory mechanisms.

KLK2 antibodies are immunological tools designed to detect or inhibit KLK2 protein activity. In research, these antibodies are widely used in immunoassays (e.g., ELISA, immunohistochemistry) to study KLK2 expression patterns in prostate tissues, particularly in cancer diagnostics. Elevated KLK2 levels in serum or tissue have been associated with prostate cancer aggressiveness, making it a potential biomarker companion to PSA. Therapeutically, anti-KLK2 antibodies are being explored for targeted drug delivery or as blocking agents to interfere with cancer-related signaling pathways. Challenges include ensuring antibody specificity due to high homology within the kallikrein protease family. Recent advancements focus on developing humanized monoclonal antibodies with improved affinity and reduced cross-reactivity. While most applications remain in preclinical or early clinical stages, KLK2 antibodies represent promising candidates for advancing prostate cancer management through both diagnostic and therapeutic approaches.

       
KLK2抗体;KLK2;KLK2 Antibody;

公司简介

生物技术有限公司

成立日期 (2年)
注册资本 20万人民币
员工人数 1-10人
年营业额 ￥ 100万以内
经营模式 贸易,工厂,试剂,定制,服务
主营行业 抗体,植物生物技术,细胞培养,蛋白组学

KLK2抗体相关厂家报价

内容声明
official 进入官方账号
拨打电话 立即询价