TRBC1抗体;TRBC1 Antibody—艾普蒂

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     Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)    

  
  

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     Flow cytometric analysis of JURKAT cells using TRBC1 mouse mAb (green) and negative control (red).    

  
  

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     Immunohistochemical analysis of paraffin-embedded human spleen tissues using TRBC1 mouse mAb with DAB staining.    

  
  

The TRBC1 antibody targets the T-cell receptor beta constant region 1 (TRBC1), a component of the T-cell receptor (TCR) complex expressed on the surface of T lymphocytes. The TCR consists of alpha/beta or gamma/delta chains, with ~95% of mature T cells expressing alpha/beta TCRs. TRBC1 is one of two constant region genes (TRBC1 and TRBC2) in the TCR beta locus, enabling clonality assessment since each T cell expresses only TRBC1 or TRBC2. This feature makes TRBC1 a valuable marker for distinguishing monoclonal T-cell populations (e.g., malignancies) from polyclonal reactive T cells.

TRBC1 antibodies are widely used in flow cytometry and immunohistochemistry to detect clonal expansions in T-cell lymphoproliferative disorders, such as T-cell lymphomas. Unlike genetic clonality assays, TRBC1 staining provides rapid, cost-effective identification of clonal T cells by revealing restricted TRBC1 or TRBC2 expression. Recent advancements in monoclonal antibody development have improved specificity, allowing better discrimination between neoplastic and normal T cells. TRBC1 antibodies also support research on T-cell development, immune responses, and TCR signaling. Their clinical utility continues to grow, particularly in precision diagnostics and minimal residual disease monitoring.