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  • ITGA1抗体;ITGA1 Antibody—艾普蒂
  • ITGA1抗体;ITGA1 Antibody—艾普蒂
  • ITGA1抗体;ITGA1 Antibody—艾普蒂

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ITGA1抗体;ITGA1 Antibody—艾普蒂

Mouse Monoclonal ITGA1 Antibody
询价 20μl 起订
50μl 起订
100μl 起订
上海 更新日期：2025-05-25

上海切尔齐生物科技有限公司

VIP1年
联系人：周经理
电话：027-19371278702拨打
手机：18008634902 拨打
邮箱：nuodina88@163.com

产品详情:

中文名称：
ITGA1抗体
英文名称：
Mouse Monoclonal ITGA1 Antibody
品牌：
艾普蒂
产地：
武汉
保存条件：
Stored at -20°C for 1451 year. Avoid repeated freeze / thaw cycles.
产品类别：
抗体
重组：
否
应用：
WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性：
Human,Mouse,Rat
宿主：
Mouse
偶联物：
无
靶点：
ITGA1

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/200 - 1/1000 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM1/200 - 1/400 Human,Mouse,Rat
Elisa1/10000 Human,Mouse,Rat
   

产品详情

AliasesVLA1; CD49a
Entrez GeneID3672
clone5F9H10
WB Predicted band size130.8kDa
Host/IsotypeMouse IgG1
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenPurified recombinant fragment of humanITGA1 (AA: extra(151-364)) expressed in E. Coli.
FormulationPurified antibody in PBS with 0.05% sodium azide

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       Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)    


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       Flow cytometric analysis of Hela cells using ITGA1 mouse mAb (green) and negative control (red).    


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       Flow cytometric analysis of HrpG2 cells using ITGA1 mouse mAb (green) and negative control (red).    


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       Immunohistochemical analysis of paraffin-embedded human Lung cancer tissues using ITGA1 mouse mAb with DAB staining.    


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       Immunohistochemical analysis of paraffin-embedded human Prostate cancer tissues using ITGA1 mouse mAb with DAB staining.    


           

参考文献

以下是关于ITGA1抗体的3篇模拟参考文献(基于研究领域常见主题，非真实文献)：

1. **文献名称**：*"ITGA1 Antibody-Based Targeting of Collagen Remodeling in Fibrotic Diseases"*

**作者**：Kim, H. et al.

**摘要**：研究利用ITGA1特异性抗体抑制胶原结合活性，发现其在肺纤维化模型中可减少细胞外基质沉积，提示ITGA1可能成为抗纤维化治疗的靶点。

2. **文献名称**：*"Role of ITGA1 in Tumor Angiogenesis: Insights from Antibody Blockade Experiments"*

**作者**：Chen, L. et al.

**摘要**：通过ITGA1抗体阻断肿瘤血管内皮细胞的整合素信号，发现其显著抑制小鼠模型中肿瘤血管生成，表明ITGA1在肿瘤微环境中的关键作用。

3. **文献名称**：*"ITGA1 Expression in Inflammatory Bowel Disease: An Immunohistochemical Study"*

**作者**：Müller, S. et al.

**摘要**：采用ITGA1抗体进行组织染色，揭示其在肠道炎症区域的异常高表达，提示ITGA1可能参与肠道屏障功能障碍的病理机制。

4. **文献名称**：*"Development of a High-Affinity Anti-ITGA1 Monoclonal Antibody for Functional Studies"*

**作者**：Rodriguez, A. et al.

**摘要**：报道了一种新型抗ITGA1单克隆抗体的开发，验证了其在流式细胞术和免疫沉淀中的特异性，并用于研究ITGA1在成纤维细胞迁移中的作用。

(注：以上文献为模拟示例，实际引用请通过PubMed或Google Scholar检索关键词“ITGA1 antibody”获取具体研究。)

       

背景信息

The ITGA1 antibody targets integrin alpha-1 (ITGA1), a subunit of the α1β1 integrin heterodimer, part of the integrin family of cell adhesion receptors. Integrins mediate bidirectional signaling between cells and the extracellular matrix (ECM), influencing cell migration, proliferation, and survival. ITGA1 pairs exclusively with β1 (ITGB1) to form α1β1. a collagen/laminin receptor predominantly expressed in fibroblasts, smooth muscle cells, and certain immune cells. It plays critical roles in tissue development, wound healing, and angiogenesis by regulating ECM remodeling and cell-ECM interactions.

In research, ITGA1 antibodies are essential tools for detecting protein expression, localization, and function via techniques like immunohistochemistry (IHC), flow cytometry, and Western blotting. These antibodies help elucidate ITGA1's involvement in pathological processes, including fibrosis, cancer progression, and inflammatory diseases. For instance, ITGA1 upregulation correlates with tumor invasiveness in some cancers, while its dysregulation is linked to aberrant collagen deposition in fibrotic disorders. Additionally, studies explore ITGA1 as a potential therapeutic target, with blocking antibodies tested in preclinical models to inhibit pathogenic cell adhesion or signaling.

Available as monoclonal or polyclonal formats, ITGA1 antibodies vary in species reactivity (e.g., human, mouse, rat) and applications, requiring validation for specificity. Their utility spans basic research to translational studies, contributing to understanding integrin-mediated mechanisms in health and disease.

       
ITGA1抗体;ITGA1;ITGA1 Antibody;

公司简介

生物技术有限公司

成立日期 (2年)
注册资本 20万人民币
员工人数 1-10人
年营业额 ￥ 100万以内
经营模式 贸易,工厂,试剂,定制,服务
主营行业 抗体,植物生物技术,细胞培养,蛋白组学

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