CD244抗体;CD244 Antibody—艾普蒂

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     Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)    

  
  

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     Flow cytometric analysis of THP-1 cells using CD244 mouse mAb (green) and negative control (red).    

  
  

CD244. also known as 2B4 or SLAMF4. is a cell surface receptor belonging to the signaling lymphocyte activation molecule (SLAM) family. Expressed primarily on natural killer (NK) cells, CD8⁺ T cells, and subsets of CD4⁺ T cells, it plays a dual role in immune regulation by transmitting activating or inhibitory signals depending on cellular context and ligand engagement. Its structure includes two extracellular immunoglobulin-like domains that bind to CD48. a glycosylphosphatidylinositol (GPI)-anchored ligand expressed on antigen-presenting cells and infected or transformed cells. Intracellularly, CD244 interacts with adaptors like SAP (SLAM-associated protein) to modulate downstream pathways. Mutations in SAP-related pathways are linked to immune dysregulation, such as X-linked lymphoproliferative disease (XLP).

CD244 antibodies are critical tools for studying immune cell interactions, particularly in viral infections, cancer immunity, and autoimmune disorders. They are used to block or stimulate CD244 signaling, helping to dissect its role in NK cell cytotoxicity, T cell exhaustion, and immune synapse formation. Therapeutic applications are under exploration, with anti-CD244 antibodies being investigated for targeting dysfunctional immune cells in chronic infections or enhancing antitumor responses. Recent studies also highlight its potential as a biomarker for disease progression in conditions like chronic hepatitis or leukemia. Overall, CD244 antibodies bridge basic research and clinical translation in immunology.