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  • B4GALNT1抗体;B4GALNT1 Antibody—艾普蒂
  • B4GALNT1抗体;B4GALNT1 Antibody—艾普蒂
  • B4GALNT1抗体;B4GALNT1 Antibody—艾普蒂

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B4GALNT1抗体;B4GALNT1 Antibody—艾普蒂

Mouse Monoclonal B4GALNT1 Antibody
询价 20μl 起订
50μl 起订
100μl 起订
上海 更新日期：2025-05-25

上海切尔齐生物科技有限公司

非会员
联系人：周***
电话：027***
手机：180***
邮箱：nuo***

产品详情:

中文名称：
B4GALNT1抗体
英文名称：
Mouse Monoclonal B4GALNT1 Antibody
品牌：
艾普蒂
产地：
武汉
保存条件：
Stored at -20°C for 1439 year. Avoid repeated freeze / thaw cycles.
产品类别：
抗体
重组：
否
应用：
WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性：
Human,Mouse,Rat
宿主：
Mouse
偶联物：
无
靶点：
B4GALNT1

验证与应用

应用及物种
WB1/500 - 1/2000 Human, Mouse, Monkey
IF咨询技术 Human, Mouse, Monkey
IHC1/200 - 1/1000 Human, Mouse, Monkey
ICC技术咨询 Human, Mouse, Monkey
FCM1/200 - 1/400 Human, Mouse, Monkey
Elisa1/10000 Human, Mouse, Monkey
   

产品详情

AliasesGALGT; SPG26; GALNACT; GalNAc-T
Entrez GeneID2583
clone4G11B1
WB Predicted band size58.9kDa
Host/IsotypeMouse IgG1
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Monkey
ImmunogenPurified recombinant fragment of human B4GALNT1 (AA: 26-225) expressed in E. Coli.
FormulationPurified antibody in PBS with 0.05% sodium azide

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       Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)    


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       Western blot analysis using B4GALNT1 mouse mAb against Hela (1), Jurkat (2), HepG2 (3), k562 (4), COS-7 (5), and NIH/3T3 (6) cell lysate.    


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       Flow cytometric analysis of Hela cells using B4GALNT1 mouse mAb (green) and negative control (red).    


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       Immunohistochemical analysis of paraffin-embedded human brain tissues using B4GALNT1 mouse mAb with DAB staining.    


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       Immunohistochemical analysis of paraffin-embedded human cervical cancer tissues using B4GALNT1 mouse mAb with DAB staining.    


           

参考文献

以下是3篇与B4GALNT1抗体相关的模拟参考文献示例(注：文献为示例性质，建议通过学术数据库核实真实文献)：

1. **标题**：*B4GALNT1 expression in colorectal cancer and its association with tumor progression*

**作者**：Smith A, et al.

**摘要**：研究通过免疫组化分析B4GALNT1蛋白在结肠癌组织中的表达，发现其高表达与患者预后不良相关，提示其可能作为癌症生物标志物，并利用特异性抗体验证了其在细胞膜上的定位。

2. **标题**：*B4GALNT1-mediated GD2 synthesis enhances neuroblastoma sensitivity to anti-GD2 immunotherapy*

**作者**：Zhang Y, Schultz MJ.

**摘要**：探讨B4GALNT1基因调控神经节苷脂GD2合成的机制，证明B4GALNT1敲除的神经母细胞瘤细胞对抗GD2抗体治疗的敏感性降低，研究中通过Western blot和流式细胞术使用B4GALNT1抗体验证蛋白表达。

3. **标题**：*Role of B4GALNT1 in host-pathogen interaction during enteric bacterial infection*

**作者**：Chen L, et al.

**摘要**：发现B4GALNT1缺失的小鼠肠道上皮细胞对特定大肠杆菌感染的抵抗力下降，研究利用B4GALNT1抗体阻断实验，表明该酶通过修饰细胞表面糖鞘脂结构介导病原体黏附。

(注：以上文献为基于领域知识的模拟，实际研究请查阅PubMed/Google Scholar等平台。)

       

背景信息

The B4GALNT1 antibody targets the β-1.4-N-acetylgalactosaminyltransferase 1 enzyme, encoded by the *B4GALNT1* gene. This enzyme catalyzes the transfer of N-acetylgalactosamine (GalNAc) to glycoproteins and glycolipids, playing a key role in synthesizing Sda blood group antigens and related glycoconjugates. B4GALNT1 is expressed in various tissues, including the gastrointestinal tract, kidneys, and brain, and its dysregulation has been implicated in diseases such as cancer and neurological disorders.

In research, B4GALNT1 antibodies are widely used to study protein expression, localization, and function. They help investigate the enzyme's role in cell adhesion, signaling, and tumor progression. For example, reduced B4GALNT1 expression correlates with poor prognosis in colorectal and ovarian cancers, suggesting its potential as a biomarker. Conversely, elevated levels are observed in certain neurodegenerative conditions, highlighting its diverse pathological relevance.

Antibodies against B4GALNT1 are available as monoclonal or polyclonal forms, optimized for techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). Their specificity is critical for distinguishing B4GALNT1 from related glycosyltransferases. Recent studies also explore therapeutic applications, such as targeting glycans in cancer immunotherapy. Overall, B4GALNT1 antibodies serve as essential tools for unraveling glycobiology mechanisms and advancing diagnostic or therapeutic strategies.

       
B4GALNT1抗体;B4GALNT1;B4GALNT1 Antibody;

公司简介

生物技术有限公司

成立日期 (2年)
注册资本 20万人民币
员工人数 1-10人
年营业额 ￥ 100万以内
经营模式 贸易,工厂,试剂,定制,服务
主营行业 抗体,植物生物技术,细胞培养,蛋白组学

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