RABEP2抗体;RABEP2 Antibody—艾普蒂

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     Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)    

  
  

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     Flow cytometric analysis of Hela cells using RABEP2 mouse mAb (green) and negative control (red).    

  
  

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     Immunohistochemical analysis of paraffin-embedded human bladder cancer tissues using RABEP2 mouse mAb with DAB staining.    

  
  

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     Immunohistochemical analysis of paraffin-embedded human ovarian cancer tissues using RABEP2 mouse mAb with DAB staining.    

  
  

The Rab GTPase effector protein RABEP2 (Rabaptin-5-like) is a peripheral membrane protein involved in regulating endocytic trafficking and membrane dynamics. It interacts with Rab GTPases, particularly Rab4 and Rab5. to mediate vesicle fusion and receptor sorting in early endosomes. RABEP2 is structurally related to Rabaptin-5 but exhibits distinct functional roles, including modulating epidermal growth factor receptor (EGFR) recycling and lysosomal degradation pathways. Dysregulation of RABEP2 has been implicated in cancer progression, neurological disorders, and metabolic diseases, though its precise mechanisms remain under investigation.

RABEP2 antibodies are immunological tools used to detect, quantify, or visualize RABEP2 protein expression in research. They enable studies on its subcellular localization, interaction partners, and expression patterns across tissues. Commonly validated through techniques like Western blotting, immunofluorescence, and immunoprecipitation, these antibodies help elucidate RABEP2's role in vesicular transport, autophagy, and disease pathophysiology. Commercial RABEP2 antibodies are typically raised in rabbits or mice using synthetic peptides or recombinant protein fragments. Specificity and batch consistency are critical considerations, as cross-reactivity with homologous proteins (e.g., Rabaptin-5) may occur. Recent studies using RABEP2 antibodies have highlighted its potential as a biomarker in certain cancers and neurodegenerative conditions.