FPR3抗体;FPR3 Antibody—艾普蒂

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     Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)    

  
  

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     Flow cytometric analysis of THP-1 cells using FPR3 mouse mAb (green) and negative control (red).    

  
  

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     Immunohistochemical analysis of paraffin-embedded human cervical cancer tissues using FPR3 mouse mAb with DAB staining.    

  
  

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     Immunohistochemical analysis of paraffin-embedded human rectum cancer tissues using FPR3 mouse mAb with DAB staining.    

  
  

The formyl peptide receptor 3 (FPR3) is a G protein-coupled receptor (GPCR) belonging to the FPR family, which includes FPR1. FPR2. and FPR3. These receptors are primarily expressed in immune cells, such as neutrophils, monocytes, and macrophages, and play critical roles in detecting pathogen- or damage-associated molecular patterns (PAMPs/DAMPs). FPR3 binds formylated peptides derived from bacteria or mitochondria, triggering chemotaxis, phagocytosis, and inflammatory responses. While FPR1 and FPR2 are well-studied in innate immunity, FPR3 remains less characterized, with evidence suggesting it may regulate immune resolution or counterbalance pro-inflammatory signals.

FPR3 antibodies are tools used to study receptor localization, expression, and function in immune regulation and disease contexts. They enable detection of FPR3 in tissues or cells via techniques like immunohistochemistry, flow cytometry, or Western blot. Research indicates FPR3 may influence pathologies like chronic inflammation, cancer progression, or neurodegenerative disorders, though its exact mechanisms are unclear. Some studies propose FPR3 as a potential therapeutic target, with antibodies aiding in drug development or biomarker discovery. However, challenges include cross-reactivity with other FPRs and limited commercial availability of specific antibodies. Further studies are needed to clarify FPR3's biological roles and therapeutic relevance.