NR1H2抗体;NR1H2 Antibody—艾普蒂

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     Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)    

  
  

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     Immunofluorescence analysis of Hela cells using NR1H2 mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin. Secondary antibody from Fisher (Cat#: 35503)    

  
  

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     Flow cytometric analysis of A375 cells using NR1H2 mouse mAb (green) and negative control (red).    

  
  

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     Flow cytometric analysis of Hela cells using NR1H2 mouse mAb (green) and negative control (red).    

  
  

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     Flow cytometric analysis of Raji cells using NR1H2 mouse mAb (green) and negative control (red).    

  
  

The NR1H2 antibody is a crucial tool for studying the nuclear receptor subfamily 1 group H member 2 (NR1H2), also known as liver X receptor beta (LXRβ). As a member of the ligand-activated nuclear receptor superfamily, NR1H2 forms heterodimers with retinoid X receptors (RXRs) and regulates gene expression by binding to specific DNA response elements. It plays a key role in lipid metabolism, cholesterol homeostasis, and inflammation by responding to oxysterols as endogenous ligands. NR1H2 is expressed ubiquitously, with high levels in the liver, adipose tissue, and macrophages.

Antibodies targeting NR1H2 enable researchers to detect and quantify its expression, localization, and interactions in various experimental models. They are widely used in techniques like Western blotting, immunohistochemistry, and chromatin immunoprecipitation (ChIP). Validated NR1H2 antibodies help investigate its regulatory mechanisms in diseases such as atherosclerosis, metabolic syndrome, and cancer. Specificity is critical, as NR1H2 shares structural homology with its isoform LXRα (NR1H3). High-quality antibodies undergo rigorous validation using knockout controls to ensure accurate detection. Research utilizing NR1H2 antibodies continues to uncover its therapeutic potential in modulating metabolic pathways and inflammatory responses, making it a focal point in drug development for cardiometabolic disorders.