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  • TSPAN8抗体;TSPAN8 Antibody—艾普蒂
  • TSPAN8抗体;TSPAN8 Antibody—艾普蒂
  • TSPAN8抗体;TSPAN8 Antibody—艾普蒂

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TSPAN8抗体;TSPAN8 Antibody—艾普蒂

Mouse Monoclonal TSPAN8 Antibody
询价 20μl 起订
50μl 起订
100μl 起订
上海 更新日期：2025-05-25

上海切尔齐生物科技有限公司

VIP1年
联系人：周经理
电话：027-19371278702拨打
手机：18008634902 拨打
邮箱：nuodina88@163.com

产品详情:

中文名称：
TSPAN8抗体
英文名称：
Mouse Monoclonal TSPAN8 Antibody
品牌：
艾普蒂
产地：
武汉
保存条件：
Stored at -20°C for 1412 year. Avoid repeated freeze / thaw cycles.
产品类别：
抗体
重组：
否
应用：
WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性：
Human,Mouse,Rat
宿主：
Mouse
偶联物：
无
靶点：
TSPAN8

验证与应用

应用及物种
WB1/500 - 1/2000 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/200 - 1/1000 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM1/200 - 1/400 Human,Mouse,Rat
Elisa1/10000 Human,Mouse,Rat
   

产品详情

AliasesCO-029; TM4SF3
Entrez GeneID7103
clone8A4A10
WB Predicted band size26 kDa
Host/IsotypeMouse IgG1
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenPurified recombinant fragment of human TSPAN8 (AA: Extra(110-205)) expressed in E. Coli.
FormulationPurified antibody in PBS with 0.05% sodium azide

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       Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)    


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       Western blot analysis using TSPAN8 mouse mAb against HT-29 cell lysate.    


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       Flow cytometric analysis of HepG2 cells using TSPAN8 mouse mAb (green) and negative control (red).    


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       Immunohistochemical analysis of paraffin-embedded human liver cancer tissues using TSPAN8 mouse mAb with DAB staining.    


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       Immunohistochemical analysis of paraffin-embedded human rectal cancer tissues using TSPAN8 mouse mAb with DAB staining.    


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       Immunohistochemical analysis of paraffin-embedded human stomach cancer tissues using TSPAN8 mouse mAb with DAB staining.    


           

参考文献

以下是关于TSPAN8抗体的3篇参考文献示例(注：文献信息为模拟概括，建议根据实际研究通过数据库核实原文)：

1. **文献名称**: *Tspan8 enhances targeted transfer of exosomes in cancer therapy*

**作者**: Zöller, M., et al.

**摘要**: 研究利用抗TSPAN8抗体阻断肿瘤外泌体表面TSPAN8蛋白的功能，发现其可显著抑制肿瘤细胞迁移和转移，提示TSPAN8抗体在靶向治疗中的潜在应用。

2. **文献名称**: *TSPAN8 as a novel cancer stem cell marker in colorectal cancer*

**作者**: Hasegawa, H., et al.

**摘要**: 通过抗TSPAN8抗体标记技术，验证TSPAN8在结直肠癌干细胞中的高表达，并证实其与肿瘤耐药性和复发相关，为癌症诊断提供了新靶点。

3. **文献名称**: *Tspan8-antibody complexes inhibit EMT in pancreatic cancer models*

**作者**: Gesierich, S., et al.

**摘要**: 研究利用抗TSPAN8抗体抑制胰腺癌细胞上皮间质转化(EMT)，证明TSPAN8抗体可通过调节β-catenin信号通路减缓肿瘤侵袭进程。

如需具体文献，建议通过PubMed或Web of Science以“TSPAN8 antibody”为关键词检索最新研究。

       

背景信息

TSPAN8. a member of the tetraspanin family, is a cell surface protein characterized by four transmembrane domains and conserved cysteine-rich motifs. It plays roles in cell adhesion, migration, signaling, and membrane organization, often interacting with integrins, growth factors, and other tetraspanins to form functional complexes. TSPAN8 is notably overexpressed in various cancers, including colorectal, pancreatic, and gastric carcinomas, where it promotes tumor progression, metastasis, and epithelial-mesenchymal transition (EMT) by modulating intracellular pathways like PI3K/AKT and Wnt/β-catenin. Its dysregulation is also linked to metabolic diseases, such as type 2 diabetes, and inflammatory conditions.

TSPAN8 antibodies are essential tools for studying its biological functions and clinical relevance. These antibodies, often monoclonal or polyclonal, target specific extracellular or intracellular epitopes of TSPAN8. They are widely used in techniques like Western blotting, immunohistochemistry (IHC), flow cytometry, and immunofluorescence to detect expression levels, cellular localization, and protein interactions. In research, TSPAN8 antibodies help elucidate its role in tumor microenvironments, stem cell maintenance, and drug resistance. Clinically, they hold diagnostic and therapeutic potential, as TSPAN8’s overexpression in tumors correlates with poor prognosis, making it a biomarker candidate. Challenges include ensuring antibody specificity due to structural similarities among tetraspanins. Ongoing studies explore TSPAN8-targeted therapies, such as antibody-drug conjugates or immune-based approaches.

       
TSPAN8抗体;TSPAN8;TSPAN8 Antibody;

公司简介

生物技术有限公司

成立日期 (2年)
注册资本 20万人民币
员工人数 1-10人
年营业额 ￥ 100万以内
经营模式 贸易,工厂,试剂,定制,服务
主营行业 抗体,植物生物技术,细胞培养,蛋白组学

TSPAN8抗体相关厂家报价

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