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  • GPR83抗体;GPR83 Antibody—艾普蒂
  • GPR83抗体;GPR83 Antibody—艾普蒂
  • GPR83抗体;GPR83 Antibody—艾普蒂

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GPR83抗体;GPR83 Antibody—艾普蒂

Mouse Monoclonal GPR83 Antibody
询价 20μl 起订
50μl 起订
100μl 起订
上海 更新日期：2025-05-25

上海切尔齐生物科技有限公司

VIP1年
联系人：周经理
电话：027-19371278702拨打
手机：18008634902 拨打
邮箱：nuodina88@163.com

产品详情:

中文名称：
GPR83抗体
英文名称：
Mouse Monoclonal GPR83 Antibody
品牌：
艾普蒂
产地：
武汉
保存条件：
Stored at -20°C for 1410 year. Avoid repeated freeze / thaw cycles.
产品类别：
抗体
重组：
否
应用：
WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性：
Human,Mouse,Rat
宿主：
Mouse
偶联物：
无
靶点：
GPR83

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC咨询技术 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM1/200 - 1/400 Human,Mouse,Rat
Elisa1/10000 Human,Mouse,Rat
   

产品详情

AliasesGIR; GPR72
Entrez GeneID10888
clone2A9A10
WB Predicted band size48.3kDa
Host/IsotypeMouse IgG1
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenPurified recombinant fragment of human GPR83 (AA: extra mix) expressed in E. Coli.
FormulationPurified antibody in PBS with 0.05% sodium azide

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       Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)    


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       Flow cytometric analysis of Hela cells using GPR83 mouse mAb (green) and negative control (red).    


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       Flow cytometric analysis of HepG2 cells using GPR83 mouse mAb (green) and negative control (red).    


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       Flow cytometric analysis of HT-29 cells using GPR83 mouse mAb (green) and negative control (red).    


           

参考文献

以下是关于GPR83抗体的3篇参考文献示例(内容为模拟概括，仅供参考)：

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1. **文献名称**: *"GPR83 Expression in the Rodent Brain: A Novel Receptor Localized to Neuroendocrine Regions"*

**作者**: Smith A, et al.

**摘要**: 本研究通过免疫组化技术使用GPR83特异性抗体，揭示了GPR83在小鼠下丘脑和杏仁核等神经内分泌相关脑区的高表达，提示其可能参与应激反应和能量代谢调控。

2. **文献名称**: *"Role of GPR83 in Energy Homeostasis: Insights from Antibody-Based Knockdown Models"*

**作者**: Johnson R, et al.

**摘要**: 利用GPR83抗体阻断实验，发现抑制GPR83活性可减少小鼠摄食行为并改善肥胖表型，表明该受体在能量平衡中起关键作用，可能成为代谢疾病的潜在治疗靶点。

3. **文献名称**: *"Development of a High-Affinity Monoclonal Antibody for GPR83 and Its Application in Signal Transduction Studies"*

**作者**: Lee H, et al.

**摘要**: 研究团队开发了一种新型单克隆GPR83抗体，验证了其高特异性和亲和力，并通过Western blot和流式细胞术证实GPR83在激活后发生构象变化，揭示了其下游信号转导机制。

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如需获取真实文献，建议在PubMed或Web of Science平台以“GPR83 antibody”为关键词检索，并筛选近年的高相关性研究。

       

背景信息

GPR83 (G Protein-Coupled Receptor 83) is a class A G protein-coupled receptor (GPCR) predominantly expressed in the central nervous system, particularly in regions like the hypothalamus, amygdala, and hippocampus, as well as in immune tissues. It plays roles in regulating energy homeostasis, stress responses, and immune modulation. GPR83 is activated by neuropeptides such as prosaposin-derived peptides and interacts with melanocortin-3 receptor (MC3R), suggesting involvement in pathways linked to appetite and anxiety. Its expression is also observed in certain cancers, including thyroid carcinoma and lymphomas, hinting at potential oncogenic roles.

GPR83 antibodies are essential tools for studying the receptor's localization, expression patterns, and functional mechanisms. They are widely used in techniques like Western blotting, immunohistochemistry (IHC), and flow cytometry to detect endogenous GPR83 in tissues or cultured cells. Validated antibodies help elucidate its physiological and pathological roles, including its interplay with metabolic disorders, neurodegenerative diseases, and cancer progression. Recent studies highlight GPR83's connection to obesity and psychiatric conditions in animal models, driving interest in therapeutic targeting. However, challenges remain in confirming antibody specificity due to GPCR structural homology. Researchers prioritize antibodies verified via knockout controls or blocking peptides to ensure reliability in experimental outcomes.

       
GPR83抗体;GPR83;GPR83 Antibody;

公司简介

生物技术有限公司

成立日期 (2年)
注册资本 20万人民币
员工人数 1-10人
年营业额 ￥ 100万以内
经营模式 贸易,工厂,试剂,定制,服务
主营行业 抗体,植物生物技术,细胞培养,蛋白组学

GPR83抗体相关厂家报价

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