SCARB1抗体;SCARB1 Antibody—艾普蒂

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     Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)    

  
  

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     Western blot analysis using SCARB1 mouse mAb against Hela (1), U937 (2), and HePG2 (3) cell lysate.    

  
  

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     Flow cytometric analysis of BEL-7402 cells using SCARB1 mouse mAb (green) and negative control (red).    

  
  

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     Flow cytometric analysis of Hela cells using SCARB1 mouse mAb (green) and negative control (red).    

  
  

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     Immunohistochemical analysis of paraffin-embedded human cervical cancer tissues using SCARB1 mouse mAb with DAB staining.    

  
  

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     Immunohistochemical analysis of paraffin-embedded human lung cancer tissues using SCARB1 mouse mAb with DAB staining.    

  
  

The scavenger receptor class B type 1 (SCARB1), also known as SR-BI, is a cell surface glycoprotein that plays a critical role in cholesterol metabolism, particularly in mediating the uptake of high-density lipoprotein (HDL)-derived cholesterol and cholesteryl esters into cells. SCARB1 antibodies are essential tools for studying its expression, localization, and function in various tissues, including the liver, adrenal glands, and endothelial cells. These antibodies are widely used in techniques such as Western blotting, immunohistochemistry, flow cytometry, and immunofluorescence to investigate SCARB1's involvement in lipid transport, atherosclerosis, and metabolic disorders.

Research using SCARB1 antibodies has highlighted its dual role in health and disease. While it promotes reverse cholesterol transport (protecting against cardiovascular disease), its overexpression in certain cancers may facilitate tumor progression by enhancing lipid uptake. Antibodies targeting specific epitopes or post-translational modifications of SCARB1 help elucidate its interaction partners, regulatory mechanisms, and therapeutic potential. Species-specific SCARB1 antibodies (e.g., human, mouse, rat) enable cross-species comparative studies. Validation of antibody specificity through knockout controls remains crucial, given structural similarities within the scavenger receptor family. Ongoing studies continue to explore SCARB1's link to viral entry pathways and inflammatory responses, expanding its biomedical relevance.