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网站主页 Mouse Monoclonal UQCRC1 Antibody Mouse Monoclonal UQCRC1 Antibody
  • UQCRC1抗体;UQCRC1 Antibody—艾普蒂
  • UQCRC1抗体;UQCRC1 Antibody—艾普蒂
  • UQCRC1抗体;UQCRC1 Antibody—艾普蒂

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UQCRC1抗体;UQCRC1 Antibody—艾普蒂

Mouse Monoclonal UQCRC1 Antibody
询价 20μl 起订
50μl 起订
100μl 起订
上海 更新日期：2025-05-25

上海切尔齐生物科技有限公司

VIP1年
联系人：周经理
电话：027-19371278702拨打
手机：18008634902 拨打
邮箱：nuodina88@163.com

产品详情:

中文名称：
Mouse Monoclonal UQCRC1 Antibody
英文名称：
Mouse Monoclonal UQCRC1 Antibody
品牌：
艾普蒂
产地：
武汉
保存条件：
Stored at -20°C for 1395 year. Avoid repeated freeze / thaw cycles.
产品类别：
抗体
重组：
否
应用：
WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性：
Human,Mouse,Rat
宿主：
Mouse
偶联物：
无
靶点：
UQCRC1

验证与应用

应用及物种
WB1/500 - 1/2000 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/200 - 1/1000 Human,Mouse,Rat
ICC1/50 - 1/200 Human,Mouse,Rat
FCM1/200 - 1/400 Human,Mouse,Rat
Elisa1/10000 Human,Mouse,Rat
   

产品详情

AliasesQCR1; UQCR1; D3S3191
Entrez GeneID7384
clone1A3D12
WB Predicted band size52.6kDa
Host/IsotypeMouse IgG1
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenPurified recombinant fragment of human UQCRC1 (AA: 60-227) expressed in E. Coli.
FormulationPurified antibody in PBS with 0.05% sodium azide

+ +

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       Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)    


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       Western blot analysis using UQCRC1 mouse mAb against Hela (1), A431 (2), HepG2 (3), Hek293 (4), PC-3 (5), SH-SY5Y (6), mouse brain (7), and rat brain (8) cell lysate.    


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       Immunofluorescence analysis of Hela cells using UQCRC1 mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin. Secondary antibody from Fisher (Cat#: 35503)    


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       Flow cytometric analysis of Jurkat cells using UQCRC1 mouse mAb (green) and negative control (red).    


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       Immunohistochemical analysis of paraffin-embedded human colon tissues using UQCRC1 mouse mAb with DAB staining.    


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       Immunohistochemical analysis of paraffin-embedded human colon cancer tissues using UQCRC1 mouse mAb with DAB staining.    


           

参考文献

以下是关于UQCRC1抗体的3篇参考文献示例(文献为虚构示例，仅作格式参考)：

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1. **文献名称**: "UQCRC1 deficiency disrupts mitochondrial respiratory chain assembly and causes cardiomyopathy"

**作者**: Smith A, et al. (2020)

**摘要**: 本研究利用UQCRC1抗体通过Western blot和免疫组化分析，发现UQCRC1在小鼠心脏组织中表达下调会导致线粒体复合体III组装缺陷，进而引发心肌病，提示其在维持呼吸链功能中的关键作用。

2. **文献名称**: "A novel UQCRC1 mutation associated with Parkinson’s disease alters mitochondrial dynamics"

**作者**: Chen L, et al. (2018)

**摘要**: 通过免疫荧光染色(使用UQCRC1抗体)和蛋白质质谱分析，作者发现UQCRC1基因突变导致神经元线粒体形态异常和氧化应激增加，为帕金森病的线粒体功能障碍机制提供了证据。

3. **文献名称**: "UQCRC1 as a potential biomarker in hepatocellular carcinoma: Insights from antibody-based proteomic profiling"

**作者**: Wang Y, et al. (2021)

**摘要**: 该研究利用UQCRC1抗体对肝癌组织进行免疫组化分析，发现UQCRC1表达水平与肿瘤进展和患者生存率显著相关，提示其可能作为肝癌诊断或预后的生物标志物。

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**注意**：以上文献为示例，实际引用时需检索真实数据库(如PubMed)并核实原文信息。

       

背景信息

The UQCRC1 antibody is a research tool designed to detect and study the Ubiquinol-Cytochrome c Reductase Core Protein 1 (UQCRC1), a critical subunit of mitochondrial Complex III (cytochrome bc1 complex) in the electron transport chain (ETC). UQCRC1 plays an essential role in oxidative phosphorylation by facilitating electron transfer from ubiquinol to cytochrome c, contributing to ATP synthesis. Dysregulation or mutations in UQCRC1 have been linked to mitochondrial disorders, metabolic diseases, and cancer, making it a target for investigating cellular energy metabolism and disease mechanisms.

UQCRC1 antibodies are commonly used in techniques like Western blotting, immunofluorescence, and immunoprecipitation to assess protein expression, localization, and interactions. These antibodies help researchers explore UQCRC1's role in mitochondrial function, apoptosis, and reactive oxygen species (ROS) regulation. Commercial UQCRC1 antibodies are typically raised in rabbits or mice, available as monoclonal or polyclonal variants, with validation in specific applications and species (e.g., human, mouse, rat).

Recent studies highlight UQCRC1's potential involvement in cancer progression, neurodegeneration (e.g., Parkinson's disease), and metabolic syndromes, underscoring its biomedical relevance. However, users must verify antibody specificity due to potential cross-reactivity with homologous proteins. Proper controls and validation in experimental models remain crucial for reliable data interpretation.

       
UQCRC1抗体;UQCRC1;UQCRC1 Antibody;

公司简介

生物技术有限公司

成立日期 (2年)
注册资本 20万人民币
员工人数 1-10人
年营业额 ￥ 100万以内
经营模式 贸易,工厂,试剂,定制,服务
主营行业 抗体,植物生物技术,细胞培养,蛋白组学

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