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网站主页 Mouse Monoclonal HDAC1 Antibody Mouse Monoclonal HDAC1 Antibody
  • HDAC1抗体;HDAC1 Antibody—艾普蒂
  • HDAC1抗体;HDAC1 Antibody—艾普蒂
  • HDAC1抗体;HDAC1 Antibody—艾普蒂

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HDAC1抗体;HDAC1 Antibody—艾普蒂

Mouse Monoclonal HDAC1 Antibody
询价 20μl 起订
50μl 起订
100μl 起订
上海 更新日期：2025-05-25

上海切尔齐生物科技有限公司

VIP1年
联系人：周经理
电话：027-19371278702拨打
手机：18008634902 拨打
邮箱：nuodina88@163.com

产品详情:

中文名称：
Mouse Monoclonal HDAC1 Antibody
英文名称：
Mouse Monoclonal HDAC1 Antibody
品牌：
艾普蒂
产地：
武汉
保存条件：
Stored at -20°C for 1367 year. Avoid repeated freeze / thaw cycles.
产品类别：
抗体
重组：
否
应用：
WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性：
Human,Mouse,Rat
宿主：
Mouse
偶联物：
无
靶点：
HDAC1

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/200 - 1/1000 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM1/200 - 1/400 Human,Mouse,Rat
Elisa1/10000 Human,Mouse,Rat
   

产品详情

AliasesHD1; RPD3; KDAC1; GON-10; RPD3L1
Entrez GeneID3065
clone1B6A7
WB Predicted band size55.1kDa
Host/IsotypeMouse IgG1
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenPurified recombinant fragment of human HDAC1 (AA: 321-482) expressed in E. Coli.
FormulationPurified antibody in PBS with 0.05% sodium azide

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       Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)    


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       Western blot analysis using HDAC1 mouse mAb against NIH/3T3 (1), Hela (2), Raw264.7 (3), K562 (4), Jurkat (5), C6 (6), and Raji (7) cell lysate.    


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       Flow cytometric analysis of Raji cells using HDAC1 mouse mAb (green) and negative control (red).    


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       Immunohistochemical analysis of paraffin-embedded human brain tissues using HDAC1 mouse mAb with DAB staining.    


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       Immunohistochemical analysis of paraffin-embedded human bladder cancer tissues using HDAC1 mouse mAb with DAB staining.    


           

参考文献

以下是关于HDAC1抗体的3篇参考文献及其摘要概括：

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1. **文献名称**：*HDAC1 links early life stress to impaired synaptic plasticity and depression*

**作者**：J. F. Covington III et al.

**摘要**：该研究通过免疫印迹(Western blot)和免疫组化(IHC)分析，发现HDAC1在小鼠海马体中的表达与早期压力诱导的突触可塑性损伤相关。研究使用特异性HDAC1抗体证实其参与表观遗传调控，并关联抑郁症的分子机制。

2. **文献名称**：*Selective inhibition of HDAC1 activates SOX2-mediated enhancer to reprogram fibroblast into neural stem cell*

**作者**：Y. Li et al.

**摘要**：本文利用HDAC1特异性抗体进行染色质免疫沉淀测序(ChIP-seq)，揭示了HDAC1通过调控SOX2增强子区域抑制成纤维细胞向神经干细胞的转化。研究强调了HDAC1在细胞重编程中的关键作用。

3. **文献名称**：*HDAC1 modulates OGG1-mediated oxidative DNA damage repair*

**作者**：M. A. Hassan et al.

**摘要**：通过免疫共沉淀(Co-IP)和免疫荧光技术，研究发现HDAC1与DNA修复酶OGG1相互作用。使用HDAC1抗体阻断其活性后，氧化损伤修复效率显著下降，表明HDAC1在DNA损伤应答中的表观遗传调控功能。

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以上文献均通过HDAC1抗体进行功能研究，涵盖神经科学、细胞重编程和DNA修复等领域。如需扩展检索，可结合抗体货号(如Abcam#ab7028)或特定实验方法筛选更多研究。

       

背景信息

Histone deacetylase 1 (HDAC1) is a critical enzyme involved in epigenetic regulation, primarily functioning to remove acetyl groups from histone proteins, thereby promoting chromatin condensation and transcriptional repression. As a member of the class I HDAC family, HDAC1 is ubiquitously expressed and localizes to the nucleus, where it interacts with multiprotein complexes like Sin3. NuRD, and CoREST to regulate gene expression. It plays essential roles in cell cycle progression, differentiation, DNA repair, and tumor suppression, with dysregulation linked to cancers, neurodegenerative disorders, and inflammatory diseases.

HDAC1 antibodies are indispensable tools for studying its expression, localization, and molecular interactions. These antibodies are widely used in techniques such as Western blotting, immunoprecipitation, chromatin immunoprecipitation (ChIP), and immunofluorescence to investigate HDAC1's role in chromatin remodeling and post-translational modifications. Specific HDAC1 antibodies help distinguish it from other HDAC isoforms, enabling precise analysis of its functional contributions in diverse pathways. Researchers also utilize these antibodies to explore the therapeutic potential of HDAC inhibitors in cancer and neurological conditions. Validation of HDAC1 antibodies typically includes knockout cell lines or tissues to confirm specificity. Both monoclonal and polyclonal variants are available, with selection depending on application requirements. Reliable HDAC1 antibodies remain vital for advancing research in epigenetics and targeted drug development.

       
HDAC1抗体;HDAC1;HDAC1 Antibody;

公司简介

生物技术有限公司

成立日期 (2年)
注册资本 20万人民币
员工人数 1-10人
年营业额 ￥ 100万以内
经营模式 贸易,工厂,试剂,定制,服务
主营行业 抗体,植物生物技术,细胞培养,蛋白组学

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