CD321抗体;CD321 Antibody—艾普蒂

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     Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)    

  
  

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     Immunofluorescence analysis of Hela cells using CD321 mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor-555 phalloidin. Secondary antibody from Fisher (Cat#: 35503)    

  
  

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     Flow cytometric analysis of HT-29 cells using CD321 mouse mAb (green) and negative control (red).    

  
  

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     Immunohistochemical analysis of paraffin-embedded human liver cancer tissues using CD321 mouse mAb with DAB staining.    

  
  

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     Immunohistochemical analysis of paraffin-embedded human brain tissues using CD321 mouse mAb with DAB staining.    

  
  

**Background of CD321 Antibody**

CD321. also known as Junctional Adhesion Molecule-A (JAM-A), is a transmembrane glycoprotein belonging to the immunoglobulin superfamily. It plays a critical role in maintaining endothelial and epithelial barrier integrity, regulating cell polarization, and facilitating leukocyte transmigration during inflammation. Expressed on endothelial cells, epithelial cells, platelets, and immune cells, CD321 interacts with ligands like integrins (e.g., LFA-1) and other JAM family members to mediate cell-cell adhesion and signaling.

CD321 antibodies are tools used to study its biological functions, particularly in contexts such as vascular permeability, inflammatory diseases, cancer metastasis, and viral pathogenesis (e.g., reovirus entry). Research highlights its dual role: while CD321 supports barrier function under physiological conditions, its dysregulation is linked to pathological states, including atherosclerosis and tumor progression. Antibodies targeting CD321 often block ligand interactions or modulate downstream signaling, aiding in mechanistic studies.

Therapeutic potential is also explored, with CD321 antibodies investigated for modulating immune responses or inhibiting pathogen entry. However, complexities in its signaling networks and tissue-specific roles necessitate further research. Overall, CD321 antibodies remain vital for unraveling its contributions to health and disease.