SOX11抗体;SOX11 Antibody—艾普蒂

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     Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line: Antigen (100 ng)    

  
  

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     Flow cytometric analysis of Hela cells using SOX11 mouse mAb (green) and negative control (red).    

  
  

The SOX11 antibody is a valuable tool in biomedical research and diagnostics, targeting the SOX11 protein encoded by the *SOX11* gene, a member of the SOX (SRY-related HMG-box) transcription factor family. SOX11 plays critical roles in embryonic development, neurogenesis, and tissue regeneration, with emerging implications in cancer biology. It regulates gene expression by binding to DNA through its HMG domain, influencing cell differentiation, proliferation, and survival.

In oncology, SOX11 has gained attention as a biomarker for mantle cell lymphoma (MCL), where its overexpression aids in distinguishing MCL from other B-cell malignancies. Antibodies against SOX11 are widely used in immunohistochemistry (IHC) to detect nuclear SOX11 expression in tumor samples, enhancing diagnostic accuracy. Additionally, SOX11 is implicated in other cancers, including epithelial ovarian cancer and gliomas, where its expression correlates with tumor progression or prognosis.

SOX11 antibodies are typically developed using immunogenic peptides or recombinant proteins, validated for specificity in assays like Western blotting, IHC, and immunofluorescence. Challenges include cross-reactivity with homologous SOX proteins (e.g., SOX4. SOX12) due to conserved HMG domains, necessitating careful validation. Research applications extend to studying SOX11’s role in neural development, wound healing, and regenerative medicine.

Overall, SOX11 antibodies are pivotal in elucidating the protein’s dual roles in development and disease, offering insights into molecular pathways and potential therapeutic targets.