TMEM161B抗体—艾普蒂 新品

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     IHC-P analysis of kidney tissue by TMEM161B antibody (P15834) IHC-P was performed using sections of the formalin-fixed paraffin-embedded kidney tissue;Result: Cells in tubules are positively stained at the cell membrane, nuclei and cytoplasm.    

  
  

The TMEM161B antibody is a research tool designed to detect and study the transmembrane protein 161B (TMEM161B), a conserved yet poorly characterized protein encoded by the TMEM161B gene. As a member of the transmembrane (TMEM) family, TMEM161B is predicted to span cellular membranes, though its precise structure and biological functions remain under investigation. Emerging studies suggest its potential involvement in neurodevelopment, ion transport regulation, and cellular signaling pathways. Dysregulation of TMEM161B has been tentatively linked to neurological disorders and cancer, though mechanistic insights are limited.

TMEM161B antibodies are typically developed in hosts like rabbits or mice using immunogenic peptides or recombinant protein fragments. These antibodies enable detection of endogenous TMEM161B via techniques like Western blotting, immunohistochemistry, and immunofluorescence. Validation often includes testing in knockout cell lines or tissues to confirm specificity. Commercially available antibodies vary in clonality (monoclonal/polyclonal) and epitope targets, requiring careful selection based on experimental needs. Current research employs these antibodies to map TMEM161B's tissue distribution, subcellular localization (plasma membrane, endoplasmic reticulum), and expression changes in disease models. Challenges include limited functional data and occasional cross-reactivity issues due to homology with other TMEM proteins. As TMEM161B gains attention in connectome studies and rare disease research, its antibodies serve as critical tools for unraveling its physiological and pathological roles.