CPNE8抗体—艾普蒂

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     Black line: Control Antigen (100 ng); Purple line: Antigen(10ng); Blue line: Antigen (50 ng); Red line: Antigen (100 ng);    

  
  

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     Immunohistochemical analysis of paraffin-embedded human endometrial cancer tissues using CD7 mouse mAb with DAB staining.    

  
  

**Background of CPNE8 Antibody**

CPNE8 (Copine-8) is a calcium-dependent phospholipid-binding protein belonging to the copine family, which plays roles in membrane trafficking, signal transduction, and cellular processes like exocytosis. The CPNE8 gene is highly expressed in the brain, particularly in neurons, suggesting its involvement in neural development or function. Studies link CPNE8 to neurodegenerative diseases, including Alzheimer’s disease, where altered expression may influence amyloid-beta metabolism.

CPNE8 antibodies are essential tools for detecting and quantifying CPNE8 protein levels in research. These antibodies are typically developed using immunogenic peptides or recombinant CPNE8 fragments and validated via techniques like Western blotting, immunohistochemistry, or immunofluorescence. They enable investigations into CPNE8’s spatial expression, interaction partners, and functional mechanisms in health and disease.

Recent applications include exploring CPNE8’s role in cancer progression, such as regulating cell migration in glioblastoma, and its potential as a biomarker. Challenges remain in understanding tissue-specific isoforms and post-translational modifications. Reliable CPNE8 antibodies are critical for advancing studies on its physiological and pathological significance.