CPNE7抗体—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P09563(CPNE7 Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

The CPNE7 antibody targets Copine-7 (CPNE7), a calcium-dependent phospholipid-binding protein belonging to the copine family, which regulates membrane trafficking, signaling, and cellular adhesion. Structurally, CPNE7 contains two N-terminal C2 domains that mediate calcium-dependent membrane binding and a C-terminal von Willebrand factor A (vWA) domain implicated in protein interactions. It is expressed in various tissues, including the brain, kidney, and immune cells, and plays roles in cell differentiation, neuronal development, and tissue regeneration. Dysregulation of CPNE7 has been linked to cancers, neurodegenerative disorders, and inflammatory conditions, highlighting its potential as a therapeutic or diagnostic target.

CPNE7 antibodies are widely used in research to detect CPNE7 expression and localization via techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). They also help study CPNE7's interactions with signaling molecules, such as integrins or growth factor receptors, and its role in calcium-mediated pathways. Recent studies suggest CPNE7 may influence tumor progression by modulating metastasis-related pathways, making its antibody a valuable tool in oncology research. Additionally, in dental biology, CPNE7 is associated with odontoblast differentiation and dentin formation, expanding its relevance in regenerative medicine. Commercial CPNE7 antibodies are typically validated for specificity and sensitivity, though performance may vary across applications. Ongoing research aims to clarify its mechanistic roles and therapeutic potential.