NUDT14抗体—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human brain tissue using P09122(NUDT14 Antibody) at dilution 1/25. (Original magnification: ×200)    

  
  

The NUDT14 antibody is a research tool designed to detect and study the NUDT14 protein, a member of the nudix hydrolase family. NUDT14. also known as diadenosine tetraphosphate asymmetrical hydrolase, plays a role in nucleotide metabolism by hydrolyzing substrates like diadenosine polyphosphates and nucleotide sugars, potentially regulating cellular nucleotide pools and signaling pathways. It is implicated in diverse biological processes, including DNA repair, RNA processing, and energy homeostasis.

Antibodies targeting NUDT14 are primarily used in basic and translational research to investigate its expression patterns, subcellular localization, and functional roles. They enable techniques such as Western blotting, immunohistochemistry (IHC), immunofluorescence (IF), and immunoprecipitation (IP). Studies employing these antibodies have explored NUDT14's involvement in diseases, such as cancer, metabolic disorders, and neurological conditions. For instance, altered NUDT14 expression has been observed in certain tumors, suggesting a possible link to oncogenesis or treatment resistance.

Commercial NUDT14 antibodies are typically raised in hosts like rabbits or mice, with validation data including specificity checks via knockout controls or siRNA knockdown. However, researchers often emphasize the need for rigorous validation due to potential cross-reactivity with other nudix family proteins. Current research focuses on clarifying NUDT14's substrate specificity, regulatory mechanisms, and therapeutic potential, positioning this antibody as a critical reagent for unraveling its pathophysiological significance.