DAND5抗体—艾普蒂

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     Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane: Human heart tissue, Primary antibody: P09097(DAND5 Antibody) at dilution 1/300, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 50 seconds    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human brain tissue using P09097(DAND5 Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

The DAND5 antibody targets the DAND5 protein, also known as Cerberus, a secreted glycoprotein belonging to the DAN family of BMP (bone morphogenetic protein) antagonists. DAND5 plays critical roles in embryonic development, particularly in regulating left-right asymmetry by inhibiting Nodal, BMP, and Wnt signaling pathways. It is expressed in dynamic patterns during gastrulation and organogenesis, influencing tissue patterning and cell fate decisions. DAND5 knockout studies in model organisms, such as mice and zebrafish, reveal defects in heart development, neural tube closure, and lateralization, underscoring its importance in establishing body plan symmetry.

Aberrant DAND5 expression has been linked to congenital disorders, including heterotaxy syndromes and congenital heart defects, as well as ciliopathies due to its interaction with ciliary signaling. The DAND5 antibody is widely used in developmental biology research to visualize protein localization, assess expression levels in disease models, and investigate molecular mechanisms underlying left-right axis determination. Its applications extend to stem cell differentiation studies, where DAND5 modulation helps mimic embryonic signaling environments. Structurally, DAND5 contains a conserved cysteine-rich domain essential for ligand binding and inhibition. Recent studies also explore its potential role in cancer, particularly in modulating TGF-β superfamily signaling in tumor microenvironments. The antibody’s specificity and reliability make it a key tool for dissecting early developmental processes and related pathologies.