C8G抗体—艾普蒂

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     Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane: Human colorectal cancer tissue, Primary antibody: P09095(C8G Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 seconds    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using P09095(C8G Antibody) at dilution 1/25. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using P09095(C8G Antibody) at dilution 1/25. (Original magnification: ×200)    

  
  

The C8G antibody is a monoclonal antibody developed to target the circumsporozoite protein (CSP) of *Plasmodium falciparum*, the parasite responsible for the most severe form of malaria. CSP is a dominant surface antigen expressed during the sporozoite stage, which is critical for the parasite’s invasion of human hepatocytes. The C8G antibody specifically binds to the central repeat region of CSP, a conserved domain rich in NANP amino acid repeats, which plays a role in immune evasion and host cell interaction. This antibody emerged from efforts to design passive immunization strategies or next-generation malaria vaccines, leveraging insights from natural immune responses in individuals exposed to malaria.

Research on C8G highlighted its potent neutralizing capacity, blocking sporozoite motility and hepatocyte invasion in preclinical models. Its development was partly inspired by the partial efficacy of the RTS,S/AS01 vaccine, which also targets CSP but focuses on antibody-inducing repeats. C8G’s high affinity and specificity make it a candidate for prophylactic use or as a template for vaccine design. However, challenges remain, including genetic variability in CSP across parasite strains and the need for sustained antibody levels to ensure protection. Studies continue to explore C8G’s potential in combination therapies or engineered formats to enhance durability and breadth against diverse *Plasmodium* strains.