THEMIS2抗体—艾普蒂

The THEMIS2 (thymocyte selection-associated family member 2) antibody is a tool used to study the THEMIS2 protein, a crucial regulator in immune cell signaling. THEMIS2 belongs to the THEMIS family, which includes THEMIS1. both sharing conserved CABIT (cysteine-containing, all-β in THEMIS) domains critical for interaction with signaling molecules. Unlike THEMIS1. which is essential for T-cell development, THEMIS2 is broadly expressed in innate immune cells, such as macrophages and dendritic cells, and modulates inflammatory responses. It regulates key pathways like the TLR (Toll-like receptor) and STAT3 (signal transducer and activator of transcription 3) signaling, influencing cytokine production and cell survival. Dysregulation of THEMIS2 is implicated in autoimmune diseases, chronic inflammation, and cancer. Researchers use THEMIS2 antibodies in techniques like Western blotting, immunohistochemistry, and flow cytometry to investigate its expression, localization, and functional roles. These antibodies aid in elucidating THEMIS2’s dual role as both an activator and suppressor in immune signaling networks, offering insights into therapeutic strategies targeting immune-related disorders.