PRSS38抗体—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human brain tissue using P09088(PRSS38 Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

The PRSS38 antibody targets the protein encoded by the PRSS38 gene, a member of the trypsin-like serine protease family. Serine proteases are enzymes critical for cleaving peptide bonds, regulating diverse physiological processes such as digestion, blood coagulation, and cellular signaling. PRSS38. also known as testisin or ESP-1. is a glycosylphosphatidylinositol (GPI)-anchored protein predominantly expressed in testicular germ cells and certain cancer cells. Its precise biological role remains under investigation, but studies suggest involvement in extracellular matrix remodeling, immune modulation, and tumor progression. Aberrant PRSS38 expression has been linked to cancers, including ovarian and endometrial cancers, where it may promote invasiveness or immune evasion.

PRSS38 antibodies are essential tools for studying its expression, localization, and function. They are widely used in techniques like Western blotting, immunohistochemistry (IHC), and flow cytometry to detect PRSS38 in tissues or cell lines. Polyclonal antibodies often recognize multiple epitopes, enhancing detection sensitivity, while monoclonal antibodies offer specificity for quantitative assays. Validating PRSS38 antibodies requires confirming reactivity in knockout models or using blocking peptides to ensure target specificity. Research utilizing these antibodies has advanced understanding of PRSS38's roles in reproductive biology, cancer pathogenesis, and potential therapeutic targeting. However, challenges remain in standardizing assays due to variable glycosylation and tissue-specific isoforms of PRSS38.