SLC35E2A抗体—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using P09087(SLC35E2A Antibody) at dilution 1/25. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using P09087(SLC35E2A Antibody) at dilution 1/25. (Original magnification: ×200)    

  
  

The SLC35E2A antibody is a research tool designed to detect and study the solute carrier family 35 member E2A (SLC35E2A), a poorly characterized protein belonging to the SLC35 family of nucleotide sugar transporters. These transporters are critical for glycosylation processes, facilitating the translocation of nucleotide sugars (e.g., UDP-galactose, GDP-fucose) into the endoplasmic reticulum or Golgi apparatus for protein and lipid modification. SLC35E2A is predicted to contain multiple transmembrane domains and may play a role in cellular metabolism, though its specific substrates and biological functions remain unclear.

The antibody is typically developed in immunized hosts (e.g., rabbits or mice) using peptide antigens derived from SLC35E2A’s unique sequences. It enables the detection of endogenous SLC35E2A protein via techniques like Western blotting, immunofluorescence, or immunohistochemistry, aiding in studies of its expression patterns, subcellular localization, and potential involvement in diseases. Research suggests SLC35E2A may be linked to cancer progression or metabolic disorders, but evidence is limited.

Validation of antibody specificity often involves knockout cell lines or siRNA-mediated knockdown. Cross-reactivity with homologous proteins (e.g., SLC35E2B) must be ruled out. Current studies using this antibody are exploratory, focusing on elucidating SLC35E2A’s role in cellular physiology and pathology. Its application remains niche, reflecting the protein’s understudied status in the SLC transporter family.