ERMP1抗体—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P09069(ERMP1 Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human lung cancer tissue using P09069(ERMP1 Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

The ERMP1 (Endoplasmic Reticulum Metalloendopeptidase 1) antibody is a tool used to study the ERMP1 protein, a zinc-dependent metalloprotease localized to the endoplasmic reticulum (ER). ERMP1. also known as EROP1 or PRSM1. plays a role in ER-associated degradation (ERAD), a critical quality control pathway that identifies and degrades misfolded proteins within the ER. It is implicated in cleaving terminal hydrophobic residues from ERAD substrates, facilitating their retrotranslocation to the cytoplasm for proteasomal degradation. Dysregulation of ERMP1 has been linked to ER stress-related pathologies, including neurodegenerative diseases and cancer.

ERMP1 antibodies are primarily utilized in research to detect and quantify ERMP1 expression via techniques like Western blotting, immunohistochemistry, and immunofluorescence. These antibodies aid in exploring ERMP1's function in cellular proteostasis, stress responses, and disease mechanisms. Recent studies highlight its potential as a biomarker in certain cancers, where altered expression correlates with tumor progression or therapeutic resistance. Both monoclonal and polyclonal ERMP1 antibodies are available, with specificity validated across human and model organisms. As ERMP1's biological roles remain under active investigation, these antibodies are essential for elucidating its contributions to ER homeostasis and disease pathways.