KRT222抗体—艾普蒂

The KRT222 antibody is a research tool designed to detect keratin 22 (KRT22), a member of the keratin family of intermediate filament proteins. Keratins are critical for maintaining structural integrity in epithelial cells, contributing to cell adhesion, mechanical stability, and stress resilience. KRT22. specifically encoded by the *KRT22* gene, is classified as a type I keratin and is primarily expressed in stratified epithelial tissues, though its expression patterns and functional roles remain less characterized compared to other keratins like KRT5 or KRT14. Studies suggest KRT22 may be involved in epithelial differentiation and barrier formation. Its dysregulation has been tentatively linked to certain epithelial pathologies, including inflammatory skin disorders and carcinomas, though conclusive evidence is limited. The KRT222 antibody is commonly used in immunohistochemistry (IHC) and Western blotting to localize and quantify KRT22 in tissue samples, aiding in investigations of epithelial biology and disease mechanisms. While commercial KRT222 antibodies are available for research, their specificity and applications may vary, necessitating validation via controls. Ongoing research aims to clarify KRT22's biological significance and potential as a diagnostic or therapeutic target.