MPC1抗体—艾普蒂

+ +

•  

   

     Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane 1-4: Hela, A172 and K562 cell, Human fetal liver tissue, Primary antibody: P09053(MPC1 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 20 seconds    

  
  

•  

   

     The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P09053(MPC1 Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

•  

   

     The image is immunohistochemistry of paraffin-embedded Human breast cancer tissue using P09053(MPC1 Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

The mitochondrial pyruvate carrier 1 (MPC1) is a key protein embedded in the inner mitochondrial membrane, responsible for transporting pyruvate into the mitochondrial matrix—a critical step linking glycolysis to the tricarboxylic acid (TCA) cycle and oxidative phosphorylation. MPC1 forms a heterocomplex with MPC2. and its dysfunction is implicated in metabolic disorders, cancer, and neurodegenerative diseases. Antibodies targeting MPC1 are essential tools for studying its expression, localization, and regulatory roles in cellular metabolism.

MPC1 antibodies are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to assess protein levels in tissues or cultured cells, particularly under conditions of metabolic stress or disease. Research has shown that reduced MPC1 expression correlates with metabolic reprogramming in cancers (the Warburg effect) and insulin resistance in diabetes. Additionally, these antibodies help explore MPC1's role in neurological conditions, such as Alzheimer’s disease, where mitochondrial dysfunction is a hallmark.

The development of MPC1 antibodies has advanced understanding of mitochondrial biology and disease mechanisms, offering potential for therapeutic targeting. However, challenges remain in standardizing antibody specificity across experimental models. Overall, MPC1 antibodies remain pivotal in elucidating the interplay between mitochondrial metabolism and human health.