LMNTD1抗体—艾普蒂

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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: HEPG2 cell lysate, Primary antibody: P09052(LMNTD1 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 5 seconds    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human lung cancer tissue using P09052(LMNTD1 Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

The LMNTD1 (Lamin Tail Domain-containing 1) antibody is a tool used to study the LMNTD1 protein, a relatively less characterized member of the nuclear lamina-associated protein family. LMNTD1 is implicated in maintaining nuclear structure and function, interacting with lamins and other nuclear envelope components. It plays a role in cellular processes such as mitotic regulation, chromatin organization, and mechanical stability of the nucleus. Dysregulation of nuclear lamina proteins is linked to diseases like laminopathies, cancer, and premature aging syndromes, making LMNTD1 a potential biomarker or therapeutic target.

The antibody is primarily utilized in research applications like Western blotting, immunofluorescence, and immunohistochemistry to detect LMNTD1 expression and localization in cells or tissues. Studies have explored its expression patterns across developmental stages and disease models, particularly in cancers where nuclear envelope abnormalities are common. Challenges include limited commercial availability and the need for rigorous validation due to LMNTD1's structural similarities to other lamin-associated proteins. Ongoing research aims to clarify its precise molecular interactions and pathophysiological relevance, bridging gaps in understanding nuclear architecture and disease mechanisms.