DCXR抗体—艾普蒂

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     Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane 1-3: 293T and TM4 cell, human fetal liver tissue, Primary antibody: P09047(DCXR Antibody) at dilution 1/300, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 15 seconds    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using P09047(DCXR Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using P09047(DCXR Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

DCXR (dicarbonyl and L-xylulose reductase) is a multifunctional enzyme involved in cellular detoxification and carbohydrate metabolism. It catalyzes the NADPH-dependent reduction of dicarbonyl compounds (e.g., methylglyoxal) and L-xylulose, linking it to the pentose phosphate pathway and fructose metabolism. DCXR is highly expressed in renal proximal tubules, liver, and reproductive tissues, suggesting roles in metabolic homeostasis and detoxification processes.

DCXR antibodies are valuable tools for studying its expression, localization, and function in physiological and pathological contexts. Research highlights DCXR's association with diabetic complications due to its role in metabolizing reactive carbonyl species implicated in oxidative stress. It has also been explored as a potential biomarker in renal cell carcinoma and other cancers, where altered DCXR expression correlates with disease progression.

These antibodies enable detection via techniques like Western blotting, immunohistochemistry, and ELISA, aiding investigations into metabolic disorders, cancer biology, and toxin-mediated cellular damage. Recent studies further implicate DCXR in sperm maturation and fertility, expanding its biomedical relevance. Developing specific DCXR antibodies remains critical for elucidating its dual enzymatic roles and therapeutic potential in metabolic and neoplastic diseases.