PCID2抗体—艾普蒂

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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Human placenta tissue, Primary antibody: P09040(PCID2 Antibody) at dilution 1/250, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 seconds    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P09040(PCID2 Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using P09040(PCID2 Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

The PCID2 (PCI domain-containing protein 2) antibody targets a protein involved in critical cellular processes, including transcriptional regulation and RNA metabolism. PCID2 is a component of the TREX-2 complex, which facilitates mRNA export from the nucleus to the cytoplasm and is linked to transcription-coupled genomic stability. It contains a conserved PCI (Proteasome, COP9/signalosome, eIF3) domain, mediating interactions within multi-protein complexes. Dysregulation of PCID2 has been implicated in developmental disorders, such as Treacher Collins syndrome, and cancer progression due to its role in ribosome biogenesis and cell cycle control.

Antibodies against PCID2 are primarily used in research to study its expression, localization, and molecular interactions. They enable techniques like Western blotting, immunofluorescence, and co-immunoprecipitation to explore PCID2's function in mRNA export, DNA damage response, and transcriptional elongation. These antibodies are often raised in rabbits or mice, with validation across species including humans and mice. Researchers rely on them to investigate PCID2's role in diseases and its potential as a therapeutic target, emphasizing the need for specificity and cross-reactivity validation in experimental models.