NDUFB6抗体—艾普蒂 新品

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     Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane 1-6: 293T, Hela, PC-3, Lncap and 231 cell, Human fetal muscle tissue, Primary antibody: P09035(NDUFB6 Antibody) at dilution 1/500, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 second    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using P09035(NDUFB6 Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P09035(NDUFB6 Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

NDUFB6 antibody is a specialized tool used in biomedical research to detect and study the NDUFB6 protein, a critical subunit of mitochondrial complex I (NADH:ubiquinone oxidoreductase) within the electron transport chain (ETC). Complex I, the largest ETC component, facilitates ATP production by transferring electrons from NADH to ubiquinone, coupled with proton translocation across the mitochondrial inner membrane. NDUFB6. encoded by the nuclear *NDUFB6* gene, is one of 45 subunits comprising complex I. It plays a structural and functional role in maintaining complex I assembly/stability and regulating enzymatic activity.

NDUFB6 antibodies are widely employed in techniques like Western blotting, immunohistochemistry, and immunofluorescence to assess protein expression, localization, and abundance in tissues or cells. These antibodies are crucial for investigating mitochondrial disorders linked to complex I dysfunction, such as Leigh syndrome, cardiomyopathy, and neurodegenerative diseases. Altered NDUFB6 expression has also been implicated in cancer metabolism, diabetes, and aging-related oxidative stress, making its antibody a valuable tool for exploring disease mechanisms.

Researchers often validate NDUFB6 antibodies using knockout cell lines or tissues to confirm specificity. Challenges include cross-reactivity with homologous subunits due to conserved regions across complex I proteins. Despite this, NDUFB6 antibodies remain essential for advancing studies on mitochondrial biology, metabolic regulation, and therapeutic targeting of ETC-related pathologies.