ZNF268抗体—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P09023(ZNF268 Antibody) at dilution 1/50. (Original magnification: ×200)    

  
  

ZNF268 (Zinc Finger Protein 268) is a member of the Krüppel-associated box (KRAB) domain-containing zinc finger protein family, which plays roles in transcriptional regulation and cellular processes. The human ZNF268 gene, located on chromosome 12q13.13. encodes a protein containing multiple C2H2-type zinc finger motifs and a KRAB domain implicated in protein-protein interactions and chromatin remodeling. Studies suggest ZNF268 is involved in embryonic development, cell differentiation, and tumorigenesis. It is expressed in various normal tissues, with higher levels observed in fetal organs, but its dysregulation has been linked to cancers, including hepatocellular carcinoma, cervical cancer, and colorectal cancer.

ZNF268 antibodies are essential tools for investigating its biological functions and mechanisms. These antibodies enable detection of ZNF268 protein expression patterns via techniques like Western blotting, immunohistochemistry, and immunofluorescence. Research using ZNF268 antibodies has revealed its potential dual role in cancer—acting as a tumor suppressor in some contexts (e.g., inhibiting Wnt/β-catenin signaling) or promoting malignancy in others, possibly depending on isoform expression or post-translational modifications. Additionally, ZNF268 antibodies aid in studying its interaction partners and DNA-binding activities through chromatin immunoprecipitation (ChIP). The specificity of these antibodies is critical due to structural similarities among zinc finger proteins. Ongoing research aims to clarify ZNF268's regulatory networks and therapeutic relevance in diseases.