MORC2抗体—艾普蒂

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     Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane 1-4: 231, 293T, Hela and A172 cell lysates, Primary antibody: P09011(MORC2 Antibody) at dilution 1/300, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 20 seconds    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human lung cancer tissue using P09011(MORC2 Antibody) at dilution 1/25. (Original magnification: ×200)    

  
  

MORC2 (Microrchidia Family CW-Type Zinc Finger 2) is a member of the MORC protein family, known for its role in chromatin remodeling, transcriptional regulation, and DNA damage response. It contains an ATPase domain and a CW-type zinc finger motif, enabling interactions with chromatin and other proteins. MORC2 is implicated in epigenetic silencing, heterochromatin formation, and maintenance of genomic stability. Studies suggest its involvement in diverse biological processes, including germ cell development, adipogenesis, and neuronal function.

Dysregulation of MORC2 has been linked to human diseases. Mutations in the MORC2 gene are associated with neuropathies such as Charcot-Marie-Tooth disease type 2Z (CMT2Z) and spinal muscular atrophy (SMA)-like disorders. Additionally, MORC2 overexpression is observed in certain cancers, where it may promote tumor progression by modulating oncogenic pathways or DNA repair mechanisms.

MORC2 antibodies are essential tools for investigating its expression, localization, and molecular interactions. They are widely used in techniques like Western blotting, immunofluorescence, and chromatin immunoprecipitation (ChIP) to study MORC2's role in chromatin dynamics, disease mechanisms, and therapeutic targeting. Recent research also employs these antibodies to explore how MORC2 mutations disrupt ATPase activity or chromatin binding, contributing to neurodegeneration or cancer phenotypes. Validated MORC2 antibodies help bridge gaps in understanding its dual roles in homeostasis and pathology.